This review provides an overview of the gut-lung axis and its role in asthma. It highlights the bidirectional communication between the gut and lung, where gut microbiota plays a crucial role in regulating immune responses and influencing lung health. The review discusses the impact of gut microbiota on asthma pathogenesis, including the role of specific bacterial components and metabolites such as lipopolysaccharides (LPS) and short-chain fatty acids (SCFAs). It also explores the potential of manipulating gut microbiota through probiotics, helminth therapy, and fecal microbiota transplantation (FMT) to combat asthma. The review emphasizes the importance of understanding the gut-lung axis in asthma management and the need for further research to develop effective treatment strategies.This review provides an overview of the gut-lung axis and its role in asthma. It highlights the bidirectional communication between the gut and lung, where gut microbiota plays a crucial role in regulating immune responses and influencing lung health. The review discusses the impact of gut microbiota on asthma pathogenesis, including the role of specific bacterial components and metabolites such as lipopolysaccharides (LPS) and short-chain fatty acids (SCFAs). It also explores the potential of manipulating gut microbiota through probiotics, helminth therapy, and fecal microbiota transplantation (FMT) to combat asthma. The review emphasizes the importance of understanding the gut-lung axis in asthma management and the need for further research to develop effective treatment strategies.