The gut microbiota plays a crucial role in human metabolic health and disease. Recent research suggests that the intestinal microbiota may contribute to metabolic health and, when dysregulated, contribute to the development of various metabolic disorders, including obesity, type 2 diabetes, non-alcoholic liver disease, cardio-metabolic diseases, and malnutrition. Studies have shown that the gut microbiota influences host metabolism through mechanisms involving immune training, digestion, endocrine regulation, drug metabolism, and toxin elimination. The microbiome is composed of a vast number of bacteria, archaea, bacteriophages, eukaryotic viruses, and fungi that coexist on human surfaces and in body cavities. The majority of these microorganisms are commensal or mutualistic, and the collective genetic repertoire of the gut microbiome is much larger than the human genome. The gut microbiota is influenced by factors such as birth mode, infant feeding, lifestyle, medication, and host genetics. The microbiome has important roles in host immunity, digestion, gut endocrine function, neurological signaling, drug metabolism, and toxin elimination. The composition and function of the gut microbiota are associated with metabolic health, and dysbiosis is linked to various metabolic disorders. The microbiome-wide association study approach is used to identify genetic variants associated with a phenotype, often a disease state. This approach involves sequencing microbial DNA from intestinal or fecal samples and assembling genes to construct a cross-sampled, non-redundant microbial gene catalog. Integrated analyses of microbiome and linked metabolomes are used to identify potential mechanistic links between the gut microbiome and various metabolomes. These analyses involve clustering microbial genes, clustering metabolites, and applying non-parametric statistical tests to correlated genes and metabolites. The results can lead to the identification of specific species that harbor the genes needed to produce precursors of disease-relevant metabolites. Supervised machine learning and random forest are used to assign samples to certain categories. The gut microbiota is also involved in the regulation of metabolism, as shown by studies in mice where the gut microbiota regulates energy harvesting and storage. The gut microbiota is also involved in the development of metabolic disorders, such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease. The gut microbiota is associated with the production of trimethylamine, which is linked to the development of atherosclerosis. The gut microbiota is also involved in the development of metabolic liver diseases, such as non-alcoholic fatty liver disease. The gut microbiota is influenced by diet, exercise, and other lifestyle factors, and interventions such as probiotics, prebiotics, and postbiotics may improve metabolic health. The gut microbiota is also involved in the development of cardio-metabolic diseases, such as atherosclerosis, and the gut microbiota is associated with the production of trimethylamine, which is linked to the development of atherosclerosis. The gut microbiota is also involvedThe gut microbiota plays a crucial role in human metabolic health and disease. Recent research suggests that the intestinal microbiota may contribute to metabolic health and, when dysregulated, contribute to the development of various metabolic disorders, including obesity, type 2 diabetes, non-alcoholic liver disease, cardio-metabolic diseases, and malnutrition. Studies have shown that the gut microbiota influences host metabolism through mechanisms involving immune training, digestion, endocrine regulation, drug metabolism, and toxin elimination. The microbiome is composed of a vast number of bacteria, archaea, bacteriophages, eukaryotic viruses, and fungi that coexist on human surfaces and in body cavities. The majority of these microorganisms are commensal or mutualistic, and the collective genetic repertoire of the gut microbiome is much larger than the human genome. The gut microbiota is influenced by factors such as birth mode, infant feeding, lifestyle, medication, and host genetics. The microbiome has important roles in host immunity, digestion, gut endocrine function, neurological signaling, drug metabolism, and toxin elimination. The composition and function of the gut microbiota are associated with metabolic health, and dysbiosis is linked to various metabolic disorders. The microbiome-wide association study approach is used to identify genetic variants associated with a phenotype, often a disease state. This approach involves sequencing microbial DNA from intestinal or fecal samples and assembling genes to construct a cross-sampled, non-redundant microbial gene catalog. Integrated analyses of microbiome and linked metabolomes are used to identify potential mechanistic links between the gut microbiome and various metabolomes. These analyses involve clustering microbial genes, clustering metabolites, and applying non-parametric statistical tests to correlated genes and metabolites. The results can lead to the identification of specific species that harbor the genes needed to produce precursors of disease-relevant metabolites. Supervised machine learning and random forest are used to assign samples to certain categories. The gut microbiota is also involved in the regulation of metabolism, as shown by studies in mice where the gut microbiota regulates energy harvesting and storage. The gut microbiota is also involved in the development of metabolic disorders, such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease. The gut microbiota is associated with the production of trimethylamine, which is linked to the development of atherosclerosis. The gut microbiota is also involved in the development of metabolic liver diseases, such as non-alcoholic fatty liver disease. The gut microbiota is influenced by diet, exercise, and other lifestyle factors, and interventions such as probiotics, prebiotics, and postbiotics may improve metabolic health. The gut microbiota is also involved in the development of cardio-metabolic diseases, such as atherosclerosis, and the gut microbiota is associated with the production of trimethylamine, which is linked to the development of atherosclerosis. The gut microbiota is also involved