"Guyton and Hall: Textbook of Medical Physiology" is a classic medical physiology textbook, now in its thirteenth edition, authored by John E. Hall and published by Elsevier. It is a must-have for physicians and scientists due to its comprehensive coverage of human physiology, essential for understanding the body's functions. First published in 1956 by Arthur Guyton, the book has been regularly updated, with John Hall contributing to the ninth and tenth editions. After Guyton's death in 2003, Hall took over the responsibility of continuing and updating the book since 2006. The thirteenth edition is divided into 15 units, with 85 chapters in total. It covers a wide range of topics, including cell physiology, membrane physiology, nerve and muscle, aviation, space, deep sea diving, and nervous system physiology. The book emphasizes the importance of understanding human physiology, especially in areas like thyroid hormone's role in brain development, which has significant implications for preventing conditions like cretinism. The author highlights the need for medical education to emphasize physiology and anatomy, even as other fields like genetics and molecular biology become more prominent. The textbook is recommended for physicians and scientists seeking to advance their knowledge and stay updated with current literature. It is an open-access article under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License. The article was published in "Surgical Neurol Int" in 2017."Guyton and Hall: Textbook of Medical Physiology" is a classic medical physiology textbook, now in its thirteenth edition, authored by John E. Hall and published by Elsevier. It is a must-have for physicians and scientists due to its comprehensive coverage of human physiology, essential for understanding the body's functions. First published in 1956 by Arthur Guyton, the book has been regularly updated, with John Hall contributing to the ninth and tenth editions. After Guyton's death in 2003, Hall took over the responsibility of continuing and updating the book since 2006. The thirteenth edition is divided into 15 units, with 85 chapters in total. It covers a wide range of topics, including cell physiology, membrane physiology, nerve and muscle, aviation, space, deep sea diving, and nervous system physiology. The book emphasizes the importance of understanding human physiology, especially in areas like thyroid hormone's role in brain development, which has significant implications for preventing conditions like cretinism. The author highlights the need for medical education to emphasize physiology and anatomy, even as other fields like genetics and molecular biology become more prominent. The textbook is recommended for physicians and scientists seeking to advance their knowledge and stay updated with current literature. It is an open-access article under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License. The article was published in "Surgical Neurol Int" in 2017.