This book review by Seyed Ali Khonsary highlights the importance of "Guyton and Hall: Textbook of Medical Physiology" for practicing physicians and scientists. First published in 1956 by Professor Arthur Guyton, the textbook has been regularly updated with contributions from Professor John Hall. The latest edition, divided into 15 units and 85 chapters, covers a wide range of topics including cell and general physiology, membrane physiology, nerve and muscle, aviation and space physiology, and the nervous system. The review emphasizes the relevance of these topics to daily practice, such as the role of thyroid hormone in brain development. Despite the importance of integrating modern fields like genetics and nanotechnology into medical education, the reviewer stresses the need to maintain a strong foundation in human physiology and anatomy. The textbook is recommended as a valuable reference for those seeking to advance their knowledge in medical physiology.This book review by Seyed Ali Khonsary highlights the importance of "Guyton and Hall: Textbook of Medical Physiology" for practicing physicians and scientists. First published in 1956 by Professor Arthur Guyton, the textbook has been regularly updated with contributions from Professor John Hall. The latest edition, divided into 15 units and 85 chapters, covers a wide range of topics including cell and general physiology, membrane physiology, nerve and muscle, aviation and space physiology, and the nervous system. The review emphasizes the relevance of these topics to daily practice, such as the role of thyroid hormone in brain development. Despite the importance of integrating modern fields like genetics and nanotechnology into medical education, the reviewer stresses the need to maintain a strong foundation in human physiology and anatomy. The textbook is recommended as a valuable reference for those seeking to advance their knowledge in medical physiology.