The HMMER web server was updated in 2015 to enhance its functionality for protein homology searches. The website, available at http://www.ebi.ac.uk/Tools/hmmer/, provides access to the HMMER software suite, which includes algorithms like phmmer, hmmscan, and hmmsearch. The update introduced jackhmmer, an iterative search algorithm, and expanded the repertoire of HMM libraries, including those from CATH-Gene3D, PIRSF, Superfamily, and TIGRFAMs. The website now offers various result visualizations, such as taxonomic distribution and domain architecture, allowing users to filter results according to their needs. The search functionality was also improved with a new taxonomic filter to enhance search performance and specificity. The HMMER webserver was relocated to the European Bioinformatics Institute (EMBL-EBI), which provides better infrastructure for handling large sequence databases. The website now supports multiple HMM databases and allows users to interact with results through different views, including taxonomy and domain architecture. The iterative searching functionality was implemented, enabling users to refine search results through multiple iterations. The HMMER web server now serves as a widely used informatics resource, with the EMBL-EBI site providing the primary search infrastructure. The update also includes improved result visualization and filtering options, making it easier for users to interpret homology search results. The website is now more stable and user-friendly, with a unified branding across both the EMBL-EBI and Janelia Research Campus sites.The HMMER web server was updated in 2015 to enhance its functionality for protein homology searches. The website, available at http://www.ebi.ac.uk/Tools/hmmer/, provides access to the HMMER software suite, which includes algorithms like phmmer, hmmscan, and hmmsearch. The update introduced jackhmmer, an iterative search algorithm, and expanded the repertoire of HMM libraries, including those from CATH-Gene3D, PIRSF, Superfamily, and TIGRFAMs. The website now offers various result visualizations, such as taxonomic distribution and domain architecture, allowing users to filter results according to their needs. The search functionality was also improved with a new taxonomic filter to enhance search performance and specificity. The HMMER webserver was relocated to the European Bioinformatics Institute (EMBL-EBI), which provides better infrastructure for handling large sequence databases. The website now supports multiple HMM databases and allows users to interact with results through different views, including taxonomy and domain architecture. The iterative searching functionality was implemented, enabling users to refine search results through multiple iterations. The HMMER web server now serves as a widely used informatics resource, with the EMBL-EBI site providing the primary search infrastructure. The update also includes improved result visualization and filtering options, making it easier for users to interpret homology search results. The website is now more stable and user-friendly, with a unified branding across both the EMBL-EBI and Janelia Research Campus sites.