The second edition of Dr. Stanley F. Malamed's *Handbook of Local Anesthesia* is a comprehensive guide designed for both dental students and experienced practitioners. The book is divided into four sections: pharmacologic and clinical properties of local anesthetics and vasoconstrictors, dental local anesthesia equipment, techniques of intraoral regional anesthesia, and complications and their management. It includes discussions on newer long-acting local anesthetics like bupivacaine and etidocaine, as well as techniques such as periodontal ligament injection and non-deflecting needles. The manual is well-organized and illustrated, making it a valuable resource for dental school courses and professional reference. However, it has been criticized for its loose binding and outdated safety practices depicted in some photographs. *Drug Interactions in Anesthesia* by N. Ty Smith, M.D., and Aldo N. Corbascio, M.D., D.Sc., is a well-organized and concise reference for healthcare professionals involved in the administration of anesthetic, analgesic, or sedative agents. The book covers a wide range of topics, including pharmacological principles, drug interactions, and the effects of physiological parameters on drug action. It includes case presentations relevant to various clinical settings, enhancing the reader's ability to apply the information to real-world scenarios. The editors address the inherent complexities of the subject, providing a thorough and practical guide.The second edition of Dr. Stanley F. Malamed's *Handbook of Local Anesthesia* is a comprehensive guide designed for both dental students and experienced practitioners. The book is divided into four sections: pharmacologic and clinical properties of local anesthetics and vasoconstrictors, dental local anesthesia equipment, techniques of intraoral regional anesthesia, and complications and their management. It includes discussions on newer long-acting local anesthetics like bupivacaine and etidocaine, as well as techniques such as periodontal ligament injection and non-deflecting needles. The manual is well-organized and illustrated, making it a valuable resource for dental school courses and professional reference. However, it has been criticized for its loose binding and outdated safety practices depicted in some photographs. *Drug Interactions in Anesthesia* by N. Ty Smith, M.D., and Aldo N. Corbascio, M.D., D.Sc., is a well-organized and concise reference for healthcare professionals involved in the administration of anesthetic, analgesic, or sedative agents. The book covers a wide range of topics, including pharmacological principles, drug interactions, and the effects of physiological parameters on drug action. It includes case presentations relevant to various clinical settings, enhancing the reader's ability to apply the information to real-world scenarios. The editors address the inherent complexities of the subject, providing a thorough and practical guide.