21 June 2024 | Shamsuddin A. Bhuiyan, Mengyi Xu, Lite Yang, Evangelia Semizoglou, Parth Bhatia, Katerina I. Pantaleo, Ivan Tochitsky, Aakanksha Jain, Burcu Erdogan, Steven Blair, Victor Cat, Juliet M. Mwirigi, Ishwarya Sankaranarayanan, Diana Tavares-Ferreira, Ursula Green, Lisa A. McIvried, Bryan A. Copits, Zachariah Bertels, John S. Del Rosario, Allie J. Widman, Richard A. Slivicki, Jiwon Yi, Reza Sharif-Naeini, Clifford J. Woolf, Jochen K. Lennerz, Jessica L. Whited, Theodore J. Price, Robert W. Gereau IV, William Renthal
The study presents a harmonized atlas of the dorsal root ganglion (DRG) and trigeminal ganglion (TG) cell types, integrating data from 31 datasets across six species. The atlas describes 18 neuronal and 11 non-neuronal cell types, improving cell type annotation and transcriptomic coverage compared to individual studies. The harmonized atlas facilitates cross-study and cross-species comparisons, revealing broad transcriptomic similarities between human and mouse sensory ganglia but also notable differences. The atlas is a valuable resource for studying cell-type-specific gene expression and understanding species differences in somatosensory cell identity.The study presents a harmonized atlas of the dorsal root ganglion (DRG) and trigeminal ganglion (TG) cell types, integrating data from 31 datasets across six species. The atlas describes 18 neuronal and 11 non-neuronal cell types, improving cell type annotation and transcriptomic coverage compared to individual studies. The harmonized atlas facilitates cross-study and cross-species comparisons, revealing broad transcriptomic similarities between human and mouse sensory ganglia but also notable differences. The atlas is a valuable resource for studying cell-type-specific gene expression and understanding species differences in somatosensory cell identity.