The chapter "Head and Neck Cancer: Basic and Clinical Aspects" provides an overview of the current state of research and clinical practices in the field of head and neck cancer. Edited by Waun Ki Hong and Randal S. Weber, the book covers a wide range of topics including the role of human papillomaviruses in both benign and malignant lesions, molecular phenotyping of head and neck cancer, risk factors and genetic susceptibility, and the biology and reversal of aerodigestive tract carcinogenesis. It also discusses mechanisms of invasion, radioresistance, early detection, photodynamic therapy, chemoradiotherapy, organ preservation, and the management of clinically negative neck disease. The book aims to provide practicing physicians with the latest findings and strategies to improve the management of head and neck cancer patients, emphasizing the importance of multidisciplinary care.The chapter "Head and Neck Cancer: Basic and Clinical Aspects" provides an overview of the current state of research and clinical practices in the field of head and neck cancer. Edited by Waun Ki Hong and Randal S. Weber, the book covers a wide range of topics including the role of human papillomaviruses in both benign and malignant lesions, molecular phenotyping of head and neck cancer, risk factors and genetic susceptibility, and the biology and reversal of aerodigestive tract carcinogenesis. It also discusses mechanisms of invasion, radioresistance, early detection, photodynamic therapy, chemoradiotherapy, organ preservation, and the management of clinically negative neck disease. The book aims to provide practicing physicians with the latest findings and strategies to improve the management of head and neck cancer patients, emphasizing the importance of multidisciplinary care.