This systematic review examines the relationship between healthcare staff wellbeing, burnout, and patient safety. It analyzed 46 studies, finding that poor wellbeing and moderate to high levels of burnout are significantly associated with poorer patient safety outcomes, such as medical errors. However, the lack of prospective studies limits the ability to determine causality. The review highlights the importance of addressing staff wellbeing and burnout to improve patient safety. It also notes that while some studies found associations between burnout and patient safety, others found no significant links, and the relationship between wellbeing and patient safety was also inconsistent. The review emphasizes the need for further research, particularly prospective studies, and clearer definitions of healthcare staff wellbeing. The findings suggest that healthcare organizations should prioritize staff wellbeing and create safer work environments to enhance patient safety. The review also notes that the mechanisms underlying the association between these variables and patient safety are not fully understood. Overall, the study underscores the critical role of staff wellbeing and burnout in patient safety and calls for targeted interventions to address these issues.This systematic review examines the relationship between healthcare staff wellbeing, burnout, and patient safety. It analyzed 46 studies, finding that poor wellbeing and moderate to high levels of burnout are significantly associated with poorer patient safety outcomes, such as medical errors. However, the lack of prospective studies limits the ability to determine causality. The review highlights the importance of addressing staff wellbeing and burnout to improve patient safety. It also notes that while some studies found associations between burnout and patient safety, others found no significant links, and the relationship between wellbeing and patient safety was also inconsistent. The review emphasizes the need for further research, particularly prospective studies, and clearer definitions of healthcare staff wellbeing. The findings suggest that healthcare organizations should prioritize staff wellbeing and create safer work environments to enhance patient safety. The review also notes that the mechanisms underlying the association between these variables and patient safety are not fully understood. Overall, the study underscores the critical role of staff wellbeing and burnout in patient safety and calls for targeted interventions to address these issues.