This systematic review examines the association between healthcare professionals' wellbeing, burnout, and patient safety. The review included 46 studies that measured either wellbeing or burnout in healthcare staff and assessed patient safety. Sixteen out of 27 studies found a significant correlation between poor wellbeing and worse patient safety, while 21 out of 30 studies found a significant association between burnout and patient safety. The majority of studies suggested that poor wellbeing and moderate to high levels of burnout are associated with poor patient safety outcomes such as medical errors. However, the lack of prospective studies limits the ability to determine causality. The review highlights the need for healthcare organizations to improve employees' mental health and create safer work environments to enhance patient safety.This systematic review examines the association between healthcare professionals' wellbeing, burnout, and patient safety. The review included 46 studies that measured either wellbeing or burnout in healthcare staff and assessed patient safety. Sixteen out of 27 studies found a significant correlation between poor wellbeing and worse patient safety, while 21 out of 30 studies found a significant association between burnout and patient safety. The majority of studies suggested that poor wellbeing and moderate to high levels of burnout are associated with poor patient safety outcomes such as medical errors. However, the lack of prospective studies limits the ability to determine causality. The review highlights the need for healthcare organizations to improve employees' mental health and create safer work environments to enhance patient safety.