This article reviews the mechanisms by which plants tolerate heavy metal toxicity, focusing on the roles of transcriptomics, proteomics, metabolomics, and ionomics. Heavy metal contamination of soil and water poses significant challenges to crop productivity and quality, exacerbated by increasing population growth and food demand. Plants have evolved complex mechanisms at various levels, from molecular to whole-plant, to counteract heavy metal toxicity and improve crop productivity. Recent advances in "omic" technologies have helped identify key metabolites, transcription factors, and stress-inducible proteins involved in heavy metal tolerance, which can be utilized for developing tolerant crop varieties. The review covers the strategies plants use to cope with heavy metal toxicity, including the role of metabolites, trace elements, transcription factors, stress-inducible proteins, and plant hormones. It also discusses the mechanisms employed by metal-accumulating plants, or "metallophytes," to tolerate heavy metals. The article highlights the importance of understanding these mechanisms for improving crop resilience and reducing the risk of heavy metal contamination in food chains.This article reviews the mechanisms by which plants tolerate heavy metal toxicity, focusing on the roles of transcriptomics, proteomics, metabolomics, and ionomics. Heavy metal contamination of soil and water poses significant challenges to crop productivity and quality, exacerbated by increasing population growth and food demand. Plants have evolved complex mechanisms at various levels, from molecular to whole-plant, to counteract heavy metal toxicity and improve crop productivity. Recent advances in "omic" technologies have helped identify key metabolites, transcription factors, and stress-inducible proteins involved in heavy metal tolerance, which can be utilized for developing tolerant crop varieties. The review covers the strategies plants use to cope with heavy metal toxicity, including the role of metabolites, trace elements, transcription factors, stress-inducible proteins, and plant hormones. It also discusses the mechanisms employed by metal-accumulating plants, or "metallophytes," to tolerate heavy metals. The article highlights the importance of understanding these mechanisms for improving crop resilience and reducing the risk of heavy metal contamination in food chains.