This review discusses the health impacts of heavy metals, including arsenic, cadmium, cobalt, chromium, copper, mercury, manganese, nickel, lead, tin, and titanium. These metals are harmful to both the environment and human health, often resulting from industrial activities and environmental pollution. The review highlights the effects of heavy metal intoxication, particularly in developing countries, where exposure is more prevalent. It also explores the mechanisms by which heavy metals affect the body, including their ability to penetrate the blood-brain barrier and disrupt neurological functions. The review emphasizes the role of free radicals in heavy metal toxicity and the potential of Xanthine Oxidoreductase (XOR) in the formation of these radicals. The study shows that heavy metals like cadmium, chromium, lead, and mercury increase XOR activity, leading to higher free radical production. Pyridoxine, a form of vitamin B6, is shown to reduce XOR activity, potentially mitigating the effects of heavy metal intoxication. The review also discusses the symptoms and health risks associated with lead and mercury poisoning, including neurological damage, kidney failure, and cancer. It concludes that early detection and prevention of heavy metal exposure are crucial, especially in developing countries, to protect public health.This review discusses the health impacts of heavy metals, including arsenic, cadmium, cobalt, chromium, copper, mercury, manganese, nickel, lead, tin, and titanium. These metals are harmful to both the environment and human health, often resulting from industrial activities and environmental pollution. The review highlights the effects of heavy metal intoxication, particularly in developing countries, where exposure is more prevalent. It also explores the mechanisms by which heavy metals affect the body, including their ability to penetrate the blood-brain barrier and disrupt neurological functions. The review emphasizes the role of free radicals in heavy metal toxicity and the potential of Xanthine Oxidoreductase (XOR) in the formation of these radicals. The study shows that heavy metals like cadmium, chromium, lead, and mercury increase XOR activity, leading to higher free radical production. Pyridoxine, a form of vitamin B6, is shown to reduce XOR activity, potentially mitigating the effects of heavy metal intoxication. The review also discusses the symptoms and health risks associated with lead and mercury poisoning, including neurological damage, kidney failure, and cancer. It concludes that early detection and prevention of heavy metal exposure are crucial, especially in developing countries, to protect public health.