Heavy arch: from inflammatory bowel diseases to metabolic disorders

Heavy arch: from inflammatory bowel diseases to metabolic disorders

Received 10 January 2024 Accepted 16 April 2024 | Timon E Adolph, Moritz Meyer, Almina Jukic, Herbert Tilg
The article "Heavy arch: from inflammatory bowel diseases to metabolic disorders" by Timon E. Adolph, Moritz Meyer, Almina Jukic, and Herbert Tilg explores the intricate relationship between inflammatory bowel diseases (IBD) and metabolic disorders. Both conditions, characterized by complex and heterogeneous clinical spectra, share common inflammatory mechanisms and are increasingly prevalent due to Westernization of lifestyle and diet. The authors highlight that metabolic disorders such as obesity, metabolic syndrome (MS), and type 2 diabetes (T2D) are associated with an increased risk of IBD, and vice versa. They discuss the clinical implications of this interplay, emphasizing the need for early detection and management of metabolic conditions in IBD patients to improve patient outcomes. The article also reviews experimental studies that support the concept of a shared inflammatory backbone between IBD and metabolic disorders, influenced by dietary cues and gut microbial perturbation. Finally, the authors outline future research directions and clinical strategies to address the growing burden of these conditions.The article "Heavy arch: from inflammatory bowel diseases to metabolic disorders" by Timon E. Adolph, Moritz Meyer, Almina Jukic, and Herbert Tilg explores the intricate relationship between inflammatory bowel diseases (IBD) and metabolic disorders. Both conditions, characterized by complex and heterogeneous clinical spectra, share common inflammatory mechanisms and are increasingly prevalent due to Westernization of lifestyle and diet. The authors highlight that metabolic disorders such as obesity, metabolic syndrome (MS), and type 2 diabetes (T2D) are associated with an increased risk of IBD, and vice versa. They discuss the clinical implications of this interplay, emphasizing the need for early detection and management of metabolic conditions in IBD patients to improve patient outcomes. The article also reviews experimental studies that support the concept of a shared inflammatory backbone between IBD and metabolic disorders, influenced by dietary cues and gut microbial perturbation. Finally, the authors outline future research directions and clinical strategies to address the growing burden of these conditions.
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