This review explores the potential of hesperidin, a flavonoid abundant in orange peels, as a promising bioactive ingredient for skincare applications. The pursuit of better skin health has led to a demand for sustainable skincare products, and hesperidin, with its antioxidant, anti-inflammatory, and anticarcinogenic properties, holds significant potential. The review covers the extraction and purification methodologies of hesperidin from orange peels and discusses its key applications in skincare, including anti-aging, UV damage repair, hyperpigmentation management, wound healing, and skin cancer treatment. The novelty of this work lies in its comprehensive coverage of hesperidin's skincare applications and its demonstration of its potential as a sustainable ingredient from a circular economy perspective. The review highlights the environmental benefits of valorizing citrus by-products and the need for further research to optimize hesperidin's bioactivities and formulations.This review explores the potential of hesperidin, a flavonoid abundant in orange peels, as a promising bioactive ingredient for skincare applications. The pursuit of better skin health has led to a demand for sustainable skincare products, and hesperidin, with its antioxidant, anti-inflammatory, and anticarcinogenic properties, holds significant potential. The review covers the extraction and purification methodologies of hesperidin from orange peels and discusses its key applications in skincare, including anti-aging, UV damage repair, hyperpigmentation management, wound healing, and skin cancer treatment. The novelty of this work lies in its comprehensive coverage of hesperidin's skincare applications and its demonstration of its potential as a sustainable ingredient from a circular economy perspective. The review highlights the environmental benefits of valorizing citrus by-products and the need for further research to optimize hesperidin's bioactivities and formulations.