This review explores hesperidin, a flavonoid abundant in orange peels, as a promising skincare bioactive compound. Hesperidin is valued for its antioxidant, anti-inflammatory, and anticarcinogenic properties, making it a potential ingredient in sustainable skincare formulations. The study highlights the extraction and purification methods of hesperidin from orange peels, emphasizing its applications in skincare, including anti-aging, UV radiation damage, hyperpigmentation, wound healing, and skin cancer prevention. The review also discusses the environmental benefits of using orange peels as a source of bioactive compounds, aligning with circular economy principles. Hesperidin's potential as a sustainable ingredient is underscored, as it can be derived from agro-food by-products, reducing waste and promoting eco-friendly skincare solutions. The review covers recent advancements in hesperidin research, focusing on its biological activities and potential applications in the skincare industry. It also addresses challenges in hesperidin formulation due to its poor solubility and low lipophilicity, while highlighting new technologies that enhance its bioavailability and efficacy. Overall, the study emphasizes the importance of hesperidin in developing innovative, sustainable skincare products that address various skin concerns while minimizing environmental impact.This review explores hesperidin, a flavonoid abundant in orange peels, as a promising skincare bioactive compound. Hesperidin is valued for its antioxidant, anti-inflammatory, and anticarcinogenic properties, making it a potential ingredient in sustainable skincare formulations. The study highlights the extraction and purification methods of hesperidin from orange peels, emphasizing its applications in skincare, including anti-aging, UV radiation damage, hyperpigmentation, wound healing, and skin cancer prevention. The review also discusses the environmental benefits of using orange peels as a source of bioactive compounds, aligning with circular economy principles. Hesperidin's potential as a sustainable ingredient is underscored, as it can be derived from agro-food by-products, reducing waste and promoting eco-friendly skincare solutions. The review covers recent advancements in hesperidin research, focusing on its biological activities and potential applications in the skincare industry. It also addresses challenges in hesperidin formulation due to its poor solubility and low lipophilicity, while highlighting new technologies that enhance its bioavailability and efficacy. Overall, the study emphasizes the importance of hesperidin in developing innovative, sustainable skincare products that address various skin concerns while minimizing environmental impact.