This review provides a comprehensive overview of the recent advancements in heterogeneous iron-based catalysts for organic transformation reactions. Iron (Fe) is highlighted as a promising and sustainable alternative to noble metal catalysts due to its abundance, low cost, and low toxicity. The review covers various catalytic reactions, including cross-coupling, C–H activation, asymmetric catalysis, and cascade processes, showcasing the versatility of Fe in synthetic methodologies. Key areas of focus include mechanistic insights, challenges, and future opportunities in the field. The review also discusses the advantages of heterogeneous Fe catalysts, such as ease of separation, high stability, and selectivity, making them suitable for large-scale industrial processes. Recent advancements in C–H activation, C–C coupling, C–N bond formation, and oxidation reactions are detailed, with specific examples of effective catalysts and their applications. The review emphasizes the potential of Fe-based catalysts in driving innovation and sustainability in organic chemistry, with implications for drug discovery, materials science, and environmental remediation.This review provides a comprehensive overview of the recent advancements in heterogeneous iron-based catalysts for organic transformation reactions. Iron (Fe) is highlighted as a promising and sustainable alternative to noble metal catalysts due to its abundance, low cost, and low toxicity. The review covers various catalytic reactions, including cross-coupling, C–H activation, asymmetric catalysis, and cascade processes, showcasing the versatility of Fe in synthetic methodologies. Key areas of focus include mechanistic insights, challenges, and future opportunities in the field. The review also discusses the advantages of heterogeneous Fe catalysts, such as ease of separation, high stability, and selectivity, making them suitable for large-scale industrial processes. Recent advancements in C–H activation, C–C coupling, C–N bond formation, and oxidation reactions are detailed, with specific examples of effective catalysts and their applications. The review emphasizes the potential of Fe-based catalysts in driving innovation and sustainability in organic chemistry, with implications for drug discovery, materials science, and environmental remediation.