This article presents the synthesis and application of MnSe@NC@ReS₂ core-shell nanowires for advanced sodium- and potassium-ion batteries. The nanowires are composed of MnSe core, carbon nanotube shell (NC), and ReS₂ shell. The synthesis involves growing ReS₂ nanosheets on the surface of MnSe@NC nanowires, which are first prepared by growing ReS₂ nanosheets on MnSe nanowires. The resulting MnSe@NC@ReS₂ nanowires exhibit excellent Na⁺/K⁺ storage performance. When used as anode materials for sodium-ion batteries, the nanowires maintain a specific capacity of 300 mAh·g⁻¹ after 400 cycles at 1.0 A·g⁻¹. For potassium-ion batteries, the specific capacity remains at 120 mAh·g⁻¹ after 900 cycles at the same current density. The heterogeneous engineering and 1D-2D hybrid strategies used in this study provide an ideal approach for the synthesis of new hetero-structured anode materials with outstanding battery performance for both sodium- and potassium-ion batteries. The MnSe@NC@ReS₂ nanowires are promising anode materials due to their high specific capacity, excellent electrochemical stability, and ability to accommodate volume expansion during ion insertion/extraction processes. The synthesis process involves the preparation of MnO nanowires, followed by the formation of MnSe@NC nanowires through selenization and annealing, and finally the growth of ReS₂ nanosheets on the surface of MnSe@NC nanowires. The resulting heterostructure nanowires show great potential for use in sodium- and potassium-ion batteries.This article presents the synthesis and application of MnSe@NC@ReS₂ core-shell nanowires for advanced sodium- and potassium-ion batteries. The nanowires are composed of MnSe core, carbon nanotube shell (NC), and ReS₂ shell. The synthesis involves growing ReS₂ nanosheets on the surface of MnSe@NC nanowires, which are first prepared by growing ReS₂ nanosheets on MnSe nanowires. The resulting MnSe@NC@ReS₂ nanowires exhibit excellent Na⁺/K⁺ storage performance. When used as anode materials for sodium-ion batteries, the nanowires maintain a specific capacity of 300 mAh·g⁻¹ after 400 cycles at 1.0 A·g⁻¹. For potassium-ion batteries, the specific capacity remains at 120 mAh·g⁻¹ after 900 cycles at the same current density. The heterogeneous engineering and 1D-2D hybrid strategies used in this study provide an ideal approach for the synthesis of new hetero-structured anode materials with outstanding battery performance for both sodium- and potassium-ion batteries. The MnSe@NC@ReS₂ nanowires are promising anode materials due to their high specific capacity, excellent electrochemical stability, and ability to accommodate volume expansion during ion insertion/extraction processes. The synthesis process involves the preparation of MnO nanowires, followed by the formation of MnSe@NC nanowires through selenization and annealing, and finally the growth of ReS₂ nanosheets on the surface of MnSe@NC nanowires. The resulting heterostructure nanowires show great potential for use in sodium- and potassium-ion batteries.