Mycotoxins and their masked forms in poultry feed pose significant threats to chicken productivity and health. This review highlights the multifaceted impacts of mycotoxins on various aspects of chicken well-being, including feed efficiency, growth, immunity, antioxidants, blood biochemistry, and internal organs. Mycotoxins, toxic substances produced by fungi, can cause harm even at low contamination levels. Masked mycotoxins, which are not easily detected by conventional methods, can convert into toxic forms during digestion, exposing chickens to hidden risks despite apparent low contamination levels. The consequences of mycotoxin exposure include reduced feed efficiency, compromised growth rates, impaired immune function, altered antioxidant levels, disturbances in blood biochemical parameters, and adverse effects on internal organs. Effective management strategies, such as routine monitoring of feed ingredients and the use of detoxification methods, are essential to mitigate these impacts. The review also discusses major mycotoxins, including aflatoxins, deoxynivalenol (DON), ochratoxins, and fumonisins, and their masked forms, detailing their toxicological effects on poultry. Aflatoxins, such as AFB1, are highly toxic and can cause liver damage, immune suppression, and reduced growth. DON can lead to immune dysregulation, chronic diseases, and organ damage. Ochratoxins, particularly OTA, are nephrotoxic and can cause histopathological changes in organs. Fumonisins, such as FB1, can cause liver and kidney toxicity, as well as impair immune function. The review emphasizes the need for further research and the development of effective strategies to manage mycotoxin contamination in poultry feed to ensure the health and productivity of chickens.Mycotoxins and their masked forms in poultry feed pose significant threats to chicken productivity and health. This review highlights the multifaceted impacts of mycotoxins on various aspects of chicken well-being, including feed efficiency, growth, immunity, antioxidants, blood biochemistry, and internal organs. Mycotoxins, toxic substances produced by fungi, can cause harm even at low contamination levels. Masked mycotoxins, which are not easily detected by conventional methods, can convert into toxic forms during digestion, exposing chickens to hidden risks despite apparent low contamination levels. The consequences of mycotoxin exposure include reduced feed efficiency, compromised growth rates, impaired immune function, altered antioxidant levels, disturbances in blood biochemical parameters, and adverse effects on internal organs. Effective management strategies, such as routine monitoring of feed ingredients and the use of detoxification methods, are essential to mitigate these impacts. The review also discusses major mycotoxins, including aflatoxins, deoxynivalenol (DON), ochratoxins, and fumonisins, and their masked forms, detailing their toxicological effects on poultry. Aflatoxins, such as AFB1, are highly toxic and can cause liver damage, immune suppression, and reduced growth. DON can lead to immune dysregulation, chronic diseases, and organ damage. Ochratoxins, particularly OTA, are nephrotoxic and can cause histopathological changes in organs. Fumonisins, such as FB1, can cause liver and kidney toxicity, as well as impair immune function. The review emphasizes the need for further research and the development of effective strategies to manage mycotoxin contamination in poultry feed to ensure the health and productivity of chickens.