The study explores the use of high-entropy alloys (HEAs) as nanocatalysts to enhance the redox kinetics of sulfur in lithium-sulfur (Li-S) batteries. Traditional catalysts, which consist of a single metal element, are insufficient for accelerating the complex sulfur redox reactions involving multiple electron transfers and intermediate species. HEAs, which contain multiple elements (Co, Ni, Fe, Pd, and V), are shown to effectively adsorb lithium polysulfides (LiPSs) and accelerate their redox reactions. The incorporation of V and Pd in the HEA significantly enhances the catalytic active sites, improving both the rate capability and cycling stability of the Li-S batteries. The HEA-based batteries achieve a high capacity of 1364 mAh g−1 at 0.1 C and exhibit only a slight capacity fading rate of 0.054% per cycle over 1000 cycles at 2 C. The superior performance of HEA-catalyzed Li-S batteries demonstrates the effectiveness of HEA catalysts in accelerating stepwise sulfur redox reactions, opening new avenues for improving the electrochemical performance of Li-S batteries.The study explores the use of high-entropy alloys (HEAs) as nanocatalysts to enhance the redox kinetics of sulfur in lithium-sulfur (Li-S) batteries. Traditional catalysts, which consist of a single metal element, are insufficient for accelerating the complex sulfur redox reactions involving multiple electron transfers and intermediate species. HEAs, which contain multiple elements (Co, Ni, Fe, Pd, and V), are shown to effectively adsorb lithium polysulfides (LiPSs) and accelerate their redox reactions. The incorporation of V and Pd in the HEA significantly enhances the catalytic active sites, improving both the rate capability and cycling stability of the Li-S batteries. The HEA-based batteries achieve a high capacity of 1364 mAh g−1 at 0.1 C and exhibit only a slight capacity fading rate of 0.054% per cycle over 1000 cycles at 2 C. The superior performance of HEA-catalyzed Li-S batteries demonstrates the effectiveness of HEA catalysts in accelerating stepwise sulfur redox reactions, opening new avenues for improving the electrochemical performance of Li-S batteries.