High-entropy oxides (HEOs) are a new class of single-phase materials with unique electronic and catalytic properties, making them promising for electrocatalytic applications. This study developed a Pt/(FeCoNiCrAl)₃O₄ nanohybrid using HEO as a support for the hydrogen evolution reaction (HER). The catalyst exhibited high HER activity with a low overpotential of 22 mV at 10 mA·cm⁻², outperforming other binary, ternary, and quaternary supports. The HER activity of Pt/(FeCoNiCrAl)₃O₄ was higher than that of commercial Pt/C with significantly lower Pt loading. The catalyst showed good activity and long-term stability (60 h) in an electrolytic water-splitting device. The high activity was attributed to the effective electronic interactions between Pt and HEO, which facilitated Pt dispersion, optimized the electrochemical specific surface area, and reduced charge resistance. This study extends the application of HEOs in electrocatalysis and demonstrates their potential as supports for efficient HER catalysts. The study used a sol-gel method to prepare (FeCoNiCrAl)₃O₄ HEO with single-phase and high purity. Pt nanoparticles were then loaded onto the HEO substrate using an impregnation method. Compared to other catalysts with different oxide substrates, Pt/(FeCoNiCrAl)₃O₄ exhibited the best HER activity with an overpotential of 22 mV at 10 mA·cm⁻², significantly outperforming commercial Pt/C. The Pt/(FeCoNiCrAl)₃O₄-based anion-exchange membrane water electrolysis (AEMWE) cell provided a cell voltage of only 1.92 V to drive a current density of 200 mA·cm⁻² and maintained stable operation for over 60 h. Characterization and electrochemical results showed that the HEO substrate significantly facilitated Pt nanoparticle dispersion and electronic interactions between Pt and HEO. The HEO substrate optimized the electrochemical surface area and electron transfer compared to other supports. The results demonstrate the promising prospects of using HEOs as electrocatalytic supports.High-entropy oxides (HEOs) are a new class of single-phase materials with unique electronic and catalytic properties, making them promising for electrocatalytic applications. This study developed a Pt/(FeCoNiCrAl)₃O₄ nanohybrid using HEO as a support for the hydrogen evolution reaction (HER). The catalyst exhibited high HER activity with a low overpotential of 22 mV at 10 mA·cm⁻², outperforming other binary, ternary, and quaternary supports. The HER activity of Pt/(FeCoNiCrAl)₃O₄ was higher than that of commercial Pt/C with significantly lower Pt loading. The catalyst showed good activity and long-term stability (60 h) in an electrolytic water-splitting device. The high activity was attributed to the effective electronic interactions between Pt and HEO, which facilitated Pt dispersion, optimized the electrochemical specific surface area, and reduced charge resistance. This study extends the application of HEOs in electrocatalysis and demonstrates their potential as supports for efficient HER catalysts. The study used a sol-gel method to prepare (FeCoNiCrAl)₃O₄ HEO with single-phase and high purity. Pt nanoparticles were then loaded onto the HEO substrate using an impregnation method. Compared to other catalysts with different oxide substrates, Pt/(FeCoNiCrAl)₃O₄ exhibited the best HER activity with an overpotential of 22 mV at 10 mA·cm⁻², significantly outperforming commercial Pt/C. The Pt/(FeCoNiCrAl)₃O₄-based anion-exchange membrane water electrolysis (AEMWE) cell provided a cell voltage of only 1.92 V to drive a current density of 200 mA·cm⁻² and maintained stable operation for over 60 h. Characterization and electrochemical results showed that the HEO substrate significantly facilitated Pt nanoparticle dispersion and electronic interactions between Pt and HEO. The HEO substrate optimized the electrochemical surface area and electron transfer compared to other supports. The results demonstrate the promising prospects of using HEOs as electrocatalytic supports.