This article demonstrates high-fidelity initialization and control of electron and nuclear spins in a four-qubit register using phosphorus donors in silicon. The hyperfine interaction between electron and nuclear spins is leveraged to achieve fast and coherent operations. By initializing the nuclear spins to a specific state, the authors achieve single-electron qubit gate fidelities of 99.78 ± 0.07%, exceeding the fault-tolerant threshold for the surface code with a coherence time of 12 μs. The method involves using electric dipole spin resonance (EDSR) to perform controlled-SWAP gates, which are essential for initializing and controlling both electron and nuclear spins. The protocol is robust and can be repeated multiple times to achieve high initialization fidelity. This work paves the way for the development of large-scale quantum computers by providing a deterministic and efficient method for initializing multi-qubit registers.This article demonstrates high-fidelity initialization and control of electron and nuclear spins in a four-qubit register using phosphorus donors in silicon. The hyperfine interaction between electron and nuclear spins is leveraged to achieve fast and coherent operations. By initializing the nuclear spins to a specific state, the authors achieve single-electron qubit gate fidelities of 99.78 ± 0.07%, exceeding the fault-tolerant threshold for the surface code with a coherence time of 12 μs. The method involves using electric dipole spin resonance (EDSR) to perform controlled-SWAP gates, which are essential for initializing and controlling both electron and nuclear spins. The protocol is robust and can be repeated multiple times to achieve high initialization fidelity. This work paves the way for the development of large-scale quantum computers by providing a deterministic and efficient method for initializing multi-qubit registers.