The article by Flávio D. Fuchs and Paul K. Whelton discusses the strong evidence linking high blood pressure (BP) to cardiovascular disease (CVD). They propose that CVD is primarily caused by a rightward shift in the population distribution of BP, which is significantly higher than the biologically normal levels. This shift is more pronounced in acculturated societies compared to isolated, unacculturated societies. The authors highlight that BP is the predominant risk factor for CVD, supported by observational studies and clinical trials. They emphasize that preventing age-related increases in BP would significantly reduce vascular consequences typically attributed to aging. The article also reviews the evidence from cohort studies, randomized controlled trials (RCTs), and meta-analyses, which consistently show that lowering BP reduces the risk of CVD. The authors conclude that a comprehensive approach to improving CVD risk factors at all stages of life is necessary, with a focus on preventing age-related increases in BP.The article by Flávio D. Fuchs and Paul K. Whelton discusses the strong evidence linking high blood pressure (BP) to cardiovascular disease (CVD). They propose that CVD is primarily caused by a rightward shift in the population distribution of BP, which is significantly higher than the biologically normal levels. This shift is more pronounced in acculturated societies compared to isolated, unacculturated societies. The authors highlight that BP is the predominant risk factor for CVD, supported by observational studies and clinical trials. They emphasize that preventing age-related increases in BP would significantly reduce vascular consequences typically attributed to aging. The article also reviews the evidence from cohort studies, randomized controlled trials (RCTs), and meta-analyses, which consistently show that lowering BP reduces the risk of CVD. The authors conclude that a comprehensive approach to improving CVD risk factors at all stages of life is necessary, with a focus on preventing age-related increases in BP.