High serum procalcitonin concentrations in patients with sepsis and infection

High serum procalcitonin concentrations in patients with sepsis and infection

VOL 341: FEB 27, 1993 | MARCEL ASSICOT DOMINIQUE GENDREL HERVE CARSIN JOSEETTE RAYMOND JEAN GUILBAUD CLAUDE BOHUON
The COVID-19 Resource Centre, established by Elsevier in January 2020, provides free information in English and Mandarin on the novel coronavirus. The centre is hosted on Elsevier Connect and grants permission for all COVID-19-related research to be immediately available in PubMed Central and other public repositories, with unrestricted reuse and analysis rights. A study by Assicot et al. (1993) investigated high serum procalcitonin concentrations in patients with sepsis and infection. The study included 79 children with suspected infections and 9 severely burned patients. Procalcitonin levels were significantly higher in patients with severe bacterial infections (6-53 ng/mL) compared to those without infection (<0.1 ng/mL). Antibiotic treatment rapidly decreased procalcitonin levels. In viral infections, most patients had concentrations within or slightly above the normal range (0-1.5 ng/mL). Burn patients showed varying procalcitonin levels, with peak concentrations associated with septic complications. The study suggests that procalcitonin levels correlate with the severity of infection. A study by Al-Mohana et al. (1993) assessed the predictive value of fibrinolytic tests for hospital outcomes in 122 patients with acute upper-gastrointestinal-tract bleeding. Serum fibrin degradation products (FDP) were significantly higher in patients requiring surgery or dying compared to those surviving without transfusion or surgery. Multivariate analysis showed that doubling serum FDP was associated with a 59% increased risk of poor outcomes. These findings suggest that endogenous fibrinolysis may play a role in gastrointestinal bleeding and that fibrinolytic tests can predict adverse outcomes.The COVID-19 Resource Centre, established by Elsevier in January 2020, provides free information in English and Mandarin on the novel coronavirus. The centre is hosted on Elsevier Connect and grants permission for all COVID-19-related research to be immediately available in PubMed Central and other public repositories, with unrestricted reuse and analysis rights. A study by Assicot et al. (1993) investigated high serum procalcitonin concentrations in patients with sepsis and infection. The study included 79 children with suspected infections and 9 severely burned patients. Procalcitonin levels were significantly higher in patients with severe bacterial infections (6-53 ng/mL) compared to those without infection (<0.1 ng/mL). Antibiotic treatment rapidly decreased procalcitonin levels. In viral infections, most patients had concentrations within or slightly above the normal range (0-1.5 ng/mL). Burn patients showed varying procalcitonin levels, with peak concentrations associated with septic complications. The study suggests that procalcitonin levels correlate with the severity of infection. A study by Al-Mohana et al. (1993) assessed the predictive value of fibrinolytic tests for hospital outcomes in 122 patients with acute upper-gastrointestinal-tract bleeding. Serum fibrin degradation products (FDP) were significantly higher in patients requiring surgery or dying compared to those surviving without transfusion or surgery. Multivariate analysis showed that doubling serum FDP was associated with a 59% increased risk of poor outcomes. These findings suggest that endogenous fibrinolysis may play a role in gastrointestinal bleeding and that fibrinolytic tests can predict adverse outcomes.
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