This paper presents a novel method for direct RNA sequencing using an array of nanopores developed by Oxford Nanopore Technologies. The method allows for the direct analysis of RNA without the need for reverse transcription or PCR, which are common in traditional RNA-seq methods. This approach offers several advantages, including the ability to detect unknown transcripts, strand-specific sequencing, detection of modified nucleotides, and the generation of full-length, strand-specific sequences. The authors demonstrate the effectiveness of their method by sequencing yeast transcripts and human rhinovirus, showing high accuracy and the ability to detect modified bases. The study also highlights the potential for further improvements in throughput and accuracy through optimization of the nanopore technology and data analysis methods. The results suggest that direct RNA sequencing using nanopores could provide a more comprehensive and accurate understanding of transcriptomes.This paper presents a novel method for direct RNA sequencing using an array of nanopores developed by Oxford Nanopore Technologies. The method allows for the direct analysis of RNA without the need for reverse transcription or PCR, which are common in traditional RNA-seq methods. This approach offers several advantages, including the ability to detect unknown transcripts, strand-specific sequencing, detection of modified nucleotides, and the generation of full-length, strand-specific sequences. The authors demonstrate the effectiveness of their method by sequencing yeast transcripts and human rhinovirus, showing high accuracy and the ability to detect modified bases. The study also highlights the potential for further improvements in throughput and accuracy through optimization of the nanopore technology and data analysis methods. The results suggest that direct RNA sequencing using nanopores could provide a more comprehensive and accurate understanding of transcriptomes.