**Abstract:** Histamine intolerance is a condition characterized by the accumulation of histamine, which exceeds the body's capacity to eliminate it. This review explores various aspects of histamine intolerance, including its causes, symptoms, diagnosis, and management. Histamine is a biogenic amine with multiple biological effects, and its accumulation can lead to symptoms beyond the gastrointestinal tract. The review discusses the role of genetic factors, dietary deficiencies, and medications in histamine intolerance. It also covers the diverse symptoms associated with histamine intolerance, such as gastrointestinal issues, respiratory symptoms, skin manifestations, and cardiovascular and neurological effects. The diagnosis of histamine intolerance is challenging due to the non-specific nature of symptoms and the lack of consensus on diagnostic approaches. The review highlights the importance of combining diagnostic tests and medical history to avoid misdiagnosis. Management strategies include a low-histamine diet, DAO supplementation, and antihistamine medications. The review also addresses the challenges and future perspectives in the field, emphasizing the need for standardized diagnostic criteria, improved understanding of pathogenic mechanisms, and rigorous intervention studies.**Abstract:** Histamine intolerance is a condition characterized by the accumulation of histamine, which exceeds the body's capacity to eliminate it. This review explores various aspects of histamine intolerance, including its causes, symptoms, diagnosis, and management. Histamine is a biogenic amine with multiple biological effects, and its accumulation can lead to symptoms beyond the gastrointestinal tract. The review discusses the role of genetic factors, dietary deficiencies, and medications in histamine intolerance. It also covers the diverse symptoms associated with histamine intolerance, such as gastrointestinal issues, respiratory symptoms, skin manifestations, and cardiovascular and neurological effects. The diagnosis of histamine intolerance is challenging due to the non-specific nature of symptoms and the lack of consensus on diagnostic approaches. The review highlights the importance of combining diagnostic tests and medical history to avoid misdiagnosis. Management strategies include a low-histamine diet, DAO supplementation, and antihistamine medications. The review also addresses the challenges and future perspectives in the field, emphasizing the need for standardized diagnostic criteria, improved understanding of pathogenic mechanisms, and rigorous intervention studies.