Hodgkin's disease, first described by Thomas Hodgkin a century ago, has been the subject of extensive study. Although Hodgkin's original description included conditions not now associated with the disease, his work laid the foundation for future research. Wilks described the disease in 1856 and gave it the name used in English-speaking countries. The disease was later separated from leukemia by Virehow in 1864. Sternberg first identified the histological features, but he mistakenly described it as tuberculosis. Dorothy Reed clarified the microscopic characteristics, and subsequent researchers such as Longcope and Ziegler further expanded on this work. The exact nature and cause of Hodgkin's disease remain unclear. The disease occurs more frequently in males and is most common between the ages of 15 and 35, though cases have been reported in infants and the elderly. The first sign is usually painless lymph node enlargement, though primary swellings may occur elsewhere. The disease is not easily transmissible to animals, even monkeys. The clinical presentation and progression of the disease are outlined in tables. The study highlights the complexity of Hodgkin's disease and the ongoing challenges in understanding its etiology and pathology.Hodgkin's disease, first described by Thomas Hodgkin a century ago, has been the subject of extensive study. Although Hodgkin's original description included conditions not now associated with the disease, his work laid the foundation for future research. Wilks described the disease in 1856 and gave it the name used in English-speaking countries. The disease was later separated from leukemia by Virehow in 1864. Sternberg first identified the histological features, but he mistakenly described it as tuberculosis. Dorothy Reed clarified the microscopic characteristics, and subsequent researchers such as Longcope and Ziegler further expanded on this work. The exact nature and cause of Hodgkin's disease remain unclear. The disease occurs more frequently in males and is most common between the ages of 15 and 35, though cases have been reported in infants and the elderly. The first sign is usually painless lymph node enlargement, though primary swellings may occur elsewhere. The disease is not easily transmissible to animals, even monkeys. The clinical presentation and progression of the disease are outlined in tables. The study highlights the complexity of Hodgkin's disease and the ongoing challenges in understanding its etiology and pathology.