Hormones play a crucial role in B-cell development and autoimmunity. The development of B cells into antibody-secreting plasma cells is central to the adaptive immune system. Hormones influence B-cell development, activation, proliferation, and differentiation. In autoimmune diseases, hormonal dysregulation can promote the survival, activation, and differentiation of autoreactive B cells, leading to autoimmunity. Estrogens, prolactin (PRL), and growth hormone (GH) are associated with clinical manifestations of autoimmune diseases, while androgens like testosterone and progesterone (P4) may have protective effects. This review highlights the links between different hormones and the immune response mediated by B cells in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and multiple sclerosis (MS). Hormones such as PRL, estrogens, GH, testosterone, and P4 influence B-cell development and activation, as well as their role in autoimmune diseases. The data collected provide insights into the role of hormones in the cellular, molecular, and epigenetic mechanisms that modulate the B-cell response in health and disease. Hormones such as PRL, estrogens, GH, testosterone, and P4 influence B-cell development, activation, and survival. Estrogens increase the number of B cells and promote the development of autoimmunity. PRL increases B-cell proliferation and antibody production. GH promotes B-cell development and maturation. Testosterone has protective effects against autoimmunity. P4 has immunosuppressive effects and may regulate B-cell maturation and activation. The role of hormones in autoimmune diseases is complex, with some hormones promoting and others inhibiting autoimmunity. Understanding the role of hormones in B-cell development and autoimmunity is essential for developing therapeutic strategies for autoimmune diseases.Hormones play a crucial role in B-cell development and autoimmunity. The development of B cells into antibody-secreting plasma cells is central to the adaptive immune system. Hormones influence B-cell development, activation, proliferation, and differentiation. In autoimmune diseases, hormonal dysregulation can promote the survival, activation, and differentiation of autoreactive B cells, leading to autoimmunity. Estrogens, prolactin (PRL), and growth hormone (GH) are associated with clinical manifestations of autoimmune diseases, while androgens like testosterone and progesterone (P4) may have protective effects. This review highlights the links between different hormones and the immune response mediated by B cells in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and multiple sclerosis (MS). Hormones such as PRL, estrogens, GH, testosterone, and P4 influence B-cell development and activation, as well as their role in autoimmune diseases. The data collected provide insights into the role of hormones in the cellular, molecular, and epigenetic mechanisms that modulate the B-cell response in health and disease. Hormones such as PRL, estrogens, GH, testosterone, and P4 influence B-cell development, activation, and survival. Estrogens increase the number of B cells and promote the development of autoimmunity. PRL increases B-cell proliferation and antibody production. GH promotes B-cell development and maturation. Testosterone has protective effects against autoimmunity. P4 has immunosuppressive effects and may regulate B-cell maturation and activation. The role of hormones in autoimmune diseases is complex, with some hormones promoting and others inhibiting autoimmunity. Understanding the role of hormones in B-cell development and autoimmunity is essential for developing therapeutic strategies for autoimmune diseases.