The article "Host Cell Death and Modulation of Immune Response against Mycobacterium tuberculosis Infection" by Annie Vu, Ira Glassman, Giliene Campbell, Stephanie Yeganyan, Jessica Nguyen, Andrew Shin, and Vishwanath Venketaraman provides an in-depth review of the complex interactions between *Mycobacterium tuberculosis* (Mtb) and the host immune system, focusing on the role of host cell death pathways in controlling Mtb infection. The authors highlight the importance of granuloma formation, which involves the activation of tumor necrosis factor-alpha (TNF-α), interferons (IFNs), and reactive oxygen species (ROS) to contain and eliminate Mtb. They discuss the dual nature of apoptosis and necrosis as protective and detrimental mechanisms, respectively, and explore the molecular pathways involved in these processes. The article also reviews the potential of therapeutic agents targeting cell death signaling pathways to combat Mtb infection, including apoptosis-inducing compounds, antiapoptotic pathway inhibitors, and necrosis-modulating agents. The authors emphasize the need for a better understanding of these mechanisms to develop effective strategies for tuberculosis control and eradication.The article "Host Cell Death and Modulation of Immune Response against Mycobacterium tuberculosis Infection" by Annie Vu, Ira Glassman, Giliene Campbell, Stephanie Yeganyan, Jessica Nguyen, Andrew Shin, and Vishwanath Venketaraman provides an in-depth review of the complex interactions between *Mycobacterium tuberculosis* (Mtb) and the host immune system, focusing on the role of host cell death pathways in controlling Mtb infection. The authors highlight the importance of granuloma formation, which involves the activation of tumor necrosis factor-alpha (TNF-α), interferons (IFNs), and reactive oxygen species (ROS) to contain and eliminate Mtb. They discuss the dual nature of apoptosis and necrosis as protective and detrimental mechanisms, respectively, and explore the molecular pathways involved in these processes. The article also reviews the potential of therapeutic agents targeting cell death signaling pathways to combat Mtb infection, including apoptosis-inducing compounds, antiapoptotic pathway inhibitors, and necrosis-modulating agents. The authors emphasize the need for a better understanding of these mechanisms to develop effective strategies for tuberculosis control and eradication.