HOW MATRIX METALLOPROTEINASES REGULATE CELL BEHAVIOR

HOW MATRIX METALLOPROTEINASES REGULATE CELL BEHAVIOR

2001 | Mark D. Sternlicht and Zena Werb
Matrix metalloproteinases (MMPs) are a family of over 25 secreted and cell surface enzymes that degrade numerous extracellular substrates, including other proteinases, inhibitors, clotting factors, chemotactic molecules, growth factors, cell surface receptors, and extracellular matrix proteins. MMPs regulate various biological processes and are themselves tightly regulated. This review discusses recent advances in understanding how MMPs work, their control, and their influence on biological behavior. It highlights the relationship between MMP structure and function, and the mechanisms controlling their transcription, secretion, activation, inhibition, localization, and clearance. MMPs participate in normal and abnormal processes, and new insights into key substrates and mechanisms are emerging. Despite rapid progress, the full understanding of how MMPs regulate development, homeostasis, and disease remains elusive.Matrix metalloproteinases (MMPs) are a family of over 25 secreted and cell surface enzymes that degrade numerous extracellular substrates, including other proteinases, inhibitors, clotting factors, chemotactic molecules, growth factors, cell surface receptors, and extracellular matrix proteins. MMPs regulate various biological processes and are themselves tightly regulated. This review discusses recent advances in understanding how MMPs work, their control, and their influence on biological behavior. It highlights the relationship between MMP structure and function, and the mechanisms controlling their transcription, secretion, activation, inhibition, localization, and clearance. MMPs participate in normal and abnormal processes, and new insights into key substrates and mechanisms are emerging. Despite rapid progress, the full understanding of how MMPs regulate development, homeostasis, and disease remains elusive.
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[slides and audio] How matrix metalloproteinases regulate cell behavior.