This study identifies 180 genetic loci associated with adult height, a highly heritable trait. These loci are enriched for genes involved in biological pathways related to skeletal growth and are often located near genes known to underlie skeletal growth defects. The findings suggest that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways, providing insights into the genetic architecture of complex traits. The identified variants explain about 10% of the phenotypic variation in height, and an additional 697 loci with similar effect sizes could explain up to 16% of the variation. The presence of multiple variants within associated loci indicates allelic heterogeneity, suggesting that many unidentified causal variants may exist. The study also highlights the importance of functional and computational analyses to understand the biological mechanisms underlying these associations.This study identifies 180 genetic loci associated with adult height, a highly heritable trait. These loci are enriched for genes involved in biological pathways related to skeletal growth and are often located near genes known to underlie skeletal growth defects. The findings suggest that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways, providing insights into the genetic architecture of complex traits. The identified variants explain about 10% of the phenotypic variation in height, and an additional 697 loci with similar effect sizes could explain up to 16% of the variation. The presence of multiple variants within associated loci indicates allelic heterogeneity, suggesting that many unidentified causal variants may exist. The study also highlights the importance of functional and computational analyses to understand the biological mechanisms underlying these associations.