Hydrogel-based skin regeneration is a promising approach in tissue engineering for wound healing. This review discusses the role of hydrogels in skin tissue repair, their unique properties, and recent advancements in their application. The skin, composed of three layers, is vulnerable to damage from environmental factors, and wound healing is a complex process involving hemostasis, inflammation, proliferation, and remodeling. Traditional wound dressings have limitations, and hydrogels offer advantages such as biocompatibility, moisture retention, porosity, and the ability to mimic the extracellular matrix. Hydrogels can be designed for therapeutic agent delivery, stimuli responsiveness, and monitoring, making them effective for wound healing. Natural and synthetic polymers, including collagen, chitosan, hyaluronic acid, gelatin, alginate, dextran, fibrin, silk, PEG, PDA, PAM, PVA, CMC, and Carbopol, are used in hydrogel formulations. Hybrid and biomimetic hydrogels combine the strengths of natural and synthetic materials, enhancing mechanical strength, antibacterial properties, and tissue regeneration. The preparation of hydrogels involves physical or chemical cross-linking methods, with physical cross-linking offering biocompatibility and degradability, while chemical cross-linking provides mechanical strength and stability. The review highlights the potential of hydrogels in improving wound healing outcomes, reducing scarring, and promoting skin regeneration.Hydrogel-based skin regeneration is a promising approach in tissue engineering for wound healing. This review discusses the role of hydrogels in skin tissue repair, their unique properties, and recent advancements in their application. The skin, composed of three layers, is vulnerable to damage from environmental factors, and wound healing is a complex process involving hemostasis, inflammation, proliferation, and remodeling. Traditional wound dressings have limitations, and hydrogels offer advantages such as biocompatibility, moisture retention, porosity, and the ability to mimic the extracellular matrix. Hydrogels can be designed for therapeutic agent delivery, stimuli responsiveness, and monitoring, making them effective for wound healing. Natural and synthetic polymers, including collagen, chitosan, hyaluronic acid, gelatin, alginate, dextran, fibrin, silk, PEG, PDA, PAM, PVA, CMC, and Carbopol, are used in hydrogel formulations. Hybrid and biomimetic hydrogels combine the strengths of natural and synthetic materials, enhancing mechanical strength, antibacterial properties, and tissue regeneration. The preparation of hydrogels involves physical or chemical cross-linking methods, with physical cross-linking offering biocompatibility and degradability, while chemical cross-linking provides mechanical strength and stability. The review highlights the potential of hydrogels in improving wound healing outcomes, reducing scarring, and promoting skin regeneration.