Hydrogel-Based Skin Regeneration

Hydrogel-Based Skin Regeneration

6 February 2024 | Zohreh Arabpour, Farshad Abedi, Majid Salehi, Seyed Mahbod Baharnoori, Mohammad Soleimani, and Ali R. Djalilian
The article "Hydrogel-Based Skin Regeneration" by Zohreh Arabpour et al. provides an in-depth review of the use of hydrogels in skin wound healing and regeneration. The skin, composed of the epidermis, dermis, and hypodermis, is susceptible to damage from various factors such as injuries, infections, and comorbidities like diabetes. Traditional wound dressing methods have limitations in replicating the extracellular matrix (ECM) environment, leading to the development of tissue engineering approaches. Hydrogels, with their unique properties such as mimicking the ECM, moisture retention, porosity, biocompatibility, and biodegradability, have gained significant attention in this field. The article begins by outlining the anatomy and function of the skin, the stages of wound healing, and conventional wound dressing methods. It then delves into the structure and manufacturing methods of hydrogels, highlighting their crucial characteristics in promoting skin wound healing. Recent advancements in hydrogel dressings, including their ability to deliver therapeutic agents, respond to stimuli, and monitor the wound environment, are discussed. The article further explores the selection of polymers for hydrogel fabrication, categorizing them into natural, synthetic, hybrid, and biomimetic materials. Natural polymers like collagen, chitosan, hyaluronic acid (HA), gelatin, alginate, dextran, fibrin, and silk are detailed for their biocompatibility, biodegradability, and specific biological functions. Synthetic polymers such as polyethylene glycol (PEG), polydopamine (PDA), polyacrylamide (PAM), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC), and Carbopol are also examined for their advantages and potential modifications. Hybrid hydrogels, combining the benefits of natural and synthetic polymers, and biomimetic hydrogels, mimicking the ECM, are highlighted for their enhanced properties and applications in skin tissue engineering. The preparation methods of hydrogels, including physical and chemical cross-linking, are discussed, emphasizing the impact on gelation rate and mechanical properties. Finally, the article concludes by discussing future advancements in hydrogel materials for wound healing, emphasizing the potential of these materials to revolutionize the treatment of skin tissue defects and promote effective skin regeneration.The article "Hydrogel-Based Skin Regeneration" by Zohreh Arabpour et al. provides an in-depth review of the use of hydrogels in skin wound healing and regeneration. The skin, composed of the epidermis, dermis, and hypodermis, is susceptible to damage from various factors such as injuries, infections, and comorbidities like diabetes. Traditional wound dressing methods have limitations in replicating the extracellular matrix (ECM) environment, leading to the development of tissue engineering approaches. Hydrogels, with their unique properties such as mimicking the ECM, moisture retention, porosity, biocompatibility, and biodegradability, have gained significant attention in this field. The article begins by outlining the anatomy and function of the skin, the stages of wound healing, and conventional wound dressing methods. It then delves into the structure and manufacturing methods of hydrogels, highlighting their crucial characteristics in promoting skin wound healing. Recent advancements in hydrogel dressings, including their ability to deliver therapeutic agents, respond to stimuli, and monitor the wound environment, are discussed. The article further explores the selection of polymers for hydrogel fabrication, categorizing them into natural, synthetic, hybrid, and biomimetic materials. Natural polymers like collagen, chitosan, hyaluronic acid (HA), gelatin, alginate, dextran, fibrin, and silk are detailed for their biocompatibility, biodegradability, and specific biological functions. Synthetic polymers such as polyethylene glycol (PEG), polydopamine (PDA), polyacrylamide (PAM), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC), and Carbopol are also examined for their advantages and potential modifications. Hybrid hydrogels, combining the benefits of natural and synthetic polymers, and biomimetic hydrogels, mimicking the ECM, are highlighted for their enhanced properties and applications in skin tissue engineering. The preparation methods of hydrogels, including physical and chemical cross-linking, are discussed, emphasizing the impact on gelation rate and mechanical properties. Finally, the article concludes by discussing future advancements in hydrogel materials for wound healing, emphasizing the potential of these materials to revolutionize the treatment of skin tissue defects and promote effective skin regeneration.
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