This paper reviews the application of hydrogels in the treatment of myocardial infarction (MI), a life-threatening condition that can lead to significant cardiac damage and failure. Hydrogels, due to their good biocompatibility and mechanical properties, have emerged as promising materials for cardiac tissue engineering. The review covers various types of hydrogels, including natural and synthetic hydrogels, and their use in delivering growth factors, stem cells, and microRNAs to promote myocardial repair and regeneration. The authors discuss the design and preparation techniques of hydrogels, focusing on their ability to support myocardial function, reduce ventricular remodeling, and inhibit inflammation. They also highlight the potential of hydrogels in improving cardiac function and reducing infarct size in animal models of MI. Additionally, the paper explores the pathophysiological processes of MI, including inflammation, proliferation, and remodeling, and how different types of hydrogels can address these stages. The review concludes by emphasizing the need for further research to overcome challenges in translating hydrogel-based therapies from preclinical stages to clinical trials, while highlighting the potential of hydrogels as a novel approach to treating MI.This paper reviews the application of hydrogels in the treatment of myocardial infarction (MI), a life-threatening condition that can lead to significant cardiac damage and failure. Hydrogels, due to their good biocompatibility and mechanical properties, have emerged as promising materials for cardiac tissue engineering. The review covers various types of hydrogels, including natural and synthetic hydrogels, and their use in delivering growth factors, stem cells, and microRNAs to promote myocardial repair and regeneration. The authors discuss the design and preparation techniques of hydrogels, focusing on their ability to support myocardial function, reduce ventricular remodeling, and inhibit inflammation. They also highlight the potential of hydrogels in improving cardiac function and reducing infarct size in animal models of MI. Additionally, the paper explores the pathophysiological processes of MI, including inflammation, proliferation, and remodeling, and how different types of hydrogels can address these stages. The review concludes by emphasizing the need for further research to overcome challenges in translating hydrogel-based therapies from preclinical stages to clinical trials, while highlighting the potential of hydrogels as a novel approach to treating MI.