The article "Hydrogels and Wound Healing: Current and Future Prospects" by Varshan Gounden and Moganavelli Singh reviews the current state and future prospects of hydrogels in wound healing. The authors highlight the significant social and economic impact of managing acute and chronic wounds, emphasizing the need for effective treatments. Traditional methods such as dry dressings, surgery, negative pressure wound therapy, and hyperbaric oxygen therapy have limitations, including pain, infection, and cost. Hydrogels, which are polymer-based materials that swell in water, offer a promising solution due to their ability to provide a moist environment that facilitates wound healing. They can absorb wound exudates, exhibit shape adaptability, and be modified to incorporate active compounds like growth factors and antibacterial agents. The review discusses the properties and advantages of natural and synthetic hydrogels, including chitosan, gelatin, hyaluronic acid, alginate, polyethylene glycol (PEG), polyvinyl alcohol (PVA), and polyvinylpyrrolidone (PVP). These hydrogels are biodegradable, biocompatible, and can enhance wound healing by promoting angiogenesis, collagen formation, and cell adhesion. Advanced hydrogels, such as sprayable and "smart" hydrogels, offer additional benefits like ease of application and real-time monitoring of wound conditions. The article also explores the use of nanogels, which combine the water retention and adaptable properties of hydrogels with the customizable size and surface area of nanoparticles. Nanogels can release therapeutic agents in response to changes in pH and temperature, enhancing their effectiveness in wound healing. Overall, the review underscores the potential of hydrogels to revolutionize wound healing by providing a more efficient, effective, and patient-friendly approach to managing acute and chronic wounds.The article "Hydrogels and Wound Healing: Current and Future Prospects" by Varshan Gounden and Moganavelli Singh reviews the current state and future prospects of hydrogels in wound healing. The authors highlight the significant social and economic impact of managing acute and chronic wounds, emphasizing the need for effective treatments. Traditional methods such as dry dressings, surgery, negative pressure wound therapy, and hyperbaric oxygen therapy have limitations, including pain, infection, and cost. Hydrogels, which are polymer-based materials that swell in water, offer a promising solution due to their ability to provide a moist environment that facilitates wound healing. They can absorb wound exudates, exhibit shape adaptability, and be modified to incorporate active compounds like growth factors and antibacterial agents. The review discusses the properties and advantages of natural and synthetic hydrogels, including chitosan, gelatin, hyaluronic acid, alginate, polyethylene glycol (PEG), polyvinyl alcohol (PVA), and polyvinylpyrrolidone (PVP). These hydrogels are biodegradable, biocompatible, and can enhance wound healing by promoting angiogenesis, collagen formation, and cell adhesion. Advanced hydrogels, such as sprayable and "smart" hydrogels, offer additional benefits like ease of application and real-time monitoring of wound conditions. The article also explores the use of nanogels, which combine the water retention and adaptable properties of hydrogels with the customizable size and surface area of nanoparticles. Nanogels can release therapeutic agents in response to changes in pH and temperature, enhancing their effectiveness in wound healing. Overall, the review underscores the potential of hydrogels to revolutionize wound healing by providing a more efficient, effective, and patient-friendly approach to managing acute and chronic wounds.