Hydrogels are widely used in regenerative medicine due to their biocompatibility, flexibility in synthesis, and ability to mimic the extracellular matrix. They serve as scaffolds, drug delivery systems, and tissue barriers, enabling tissue repair and regeneration. This review discusses the properties of hydrogels important for tissue engineering, challenges in material design, and recent advances in hydrogel synthesis and microfabrication. The article highlights the importance of hydrogel structure, including crosslinking methods, mesh size, and ionic charge, in determining their functionality. It also explores the role of hydrogels in solute transport, vascularization, degradation, and macroenvironmental control. The review emphasizes the need for hydrogels to be biocompatible, biodegradable, and capable of supporting cell growth and tissue regeneration. Key challenges include ensuring proper degradation rates, maintaining mechanical properties, and controlling the microenvironment to promote tissue integration. The article also discusses the use of hydrogels in cell encapsulation, drug delivery, and tissue engineering scaffolds, highlighting their potential in improving medical treatments and addressing the limitations of current therapies. Overall, hydrogels offer a promising solution for regenerative medicine by providing a supportive environment for tissue repair and regeneration.Hydrogels are widely used in regenerative medicine due to their biocompatibility, flexibility in synthesis, and ability to mimic the extracellular matrix. They serve as scaffolds, drug delivery systems, and tissue barriers, enabling tissue repair and regeneration. This review discusses the properties of hydrogels important for tissue engineering, challenges in material design, and recent advances in hydrogel synthesis and microfabrication. The article highlights the importance of hydrogel structure, including crosslinking methods, mesh size, and ionic charge, in determining their functionality. It also explores the role of hydrogels in solute transport, vascularization, degradation, and macroenvironmental control. The review emphasizes the need for hydrogels to be biocompatible, biodegradable, and capable of supporting cell growth and tissue regeneration. Key challenges include ensuring proper degradation rates, maintaining mechanical properties, and controlling the microenvironment to promote tissue integration. The article also discusses the use of hydrogels in cell encapsulation, drug delivery, and tissue engineering scaffolds, highlighting their potential in improving medical treatments and addressing the limitations of current therapies. Overall, hydrogels offer a promising solution for regenerative medicine by providing a supportive environment for tissue repair and regeneration.