Hydrogen-rich water (HRW) has gained attention for its potential health benefits, particularly its antioxidant, anti-inflammatory, and anti-apoptotic properties. A systematic review was conducted to evaluate the potential benefits of HRW on various aspects of health, including exercise capacity, physical endurance, liver function, cardiovascular disease, mental health, COVID-19, oxidative stress, and anti-aging. The review included 25 articles, which showed encouraging preliminary results in clinical trials and studies. HRW has been found to reduce inflammatory responses, improve antioxidant capacity, and mitigate oxidative stress. It has also shown potential in managing hyperlipidemia, improving endothelial function, and reducing fatigue in chronic dialysis patients. Additionally, HRW has demonstrated anti-cancer properties and may have benefits for mental health and aging. However, further research with larger sample sizes and rigorous methodologies is needed to substantiate these findings and fully explain the mechanisms behind HRW's potential benefits. The review highlights the growing interest in HRW and its potential as an adjunctive therapeutic approach in the future.Hydrogen-rich water (HRW) has gained attention for its potential health benefits, particularly its antioxidant, anti-inflammatory, and anti-apoptotic properties. A systematic review was conducted to evaluate the potential benefits of HRW on various aspects of health, including exercise capacity, physical endurance, liver function, cardiovascular disease, mental health, COVID-19, oxidative stress, and anti-aging. The review included 25 articles, which showed encouraging preliminary results in clinical trials and studies. HRW has been found to reduce inflammatory responses, improve antioxidant capacity, and mitigate oxidative stress. It has also shown potential in managing hyperlipidemia, improving endothelial function, and reducing fatigue in chronic dialysis patients. Additionally, HRW has demonstrated anti-cancer properties and may have benefits for mental health and aging. However, further research with larger sample sizes and rigorous methodologies is needed to substantiate these findings and fully explain the mechanisms behind HRW's potential benefits. The review highlights the growing interest in HRW and its potential as an adjunctive therapeutic approach in the future.