Hyperinflammatory shock in children during COVID-19 pandemic

Hyperinflammatory shock in children during COVID-19 pandemic

May 23, 2020 | Shelley Riphagen, Xabier Gomez, Carmen Gonzalez-Martinez, Nick Wilkinson, Paraskevi Theoharis
Elsevier established a free COVID-19 resource centre in January 2020, offering information in English and Mandarin. The centre is hosted on Elsevier Connect, and Elsevier grants permission to make all its COVID-19-related research freely available in PubMed Central and other public repositories. A study reports an unusual cluster of eight children with hyperinflammatory shock during the 2020 pandemic, resembling atypical Kawasaki disease or toxic shock syndrome. These children, previously healthy, showed symptoms like high fever, rash, and gastrointestinal issues. Despite testing negative for SARS-CoV-2, they developed severe shock requiring intensive care. Some had cardiac complications, including coronary aneurysms. All received intravenous immunoglobulin and antibiotics, with most recovering. Two later tested positive for SARS-CoV-2. The study suggests a new syndrome in previously asymptomatic children, similar to Kawasaki disease shock syndrome. Elsevier also highlights a study on PCR screening of asymptomatic healthcare workers at a London hospital. The UK's COVID-19 outbreak was controlled by social distancing and lockdown. Asymptomatic infection testing is crucial for understanding disease spread and immunity. A study at Barts Health NHS Trust collected data from asymptomatic healthcare workers over 16 weeks, including nasal swabs and blood samples. The study aimed to identify factors influencing asymptomatic infection and immunity. The case-doubling time in London was around 3-4 days in March 2020. The study underscores the importance of understanding asymptomatic cases for public health strategies.Elsevier established a free COVID-19 resource centre in January 2020, offering information in English and Mandarin. The centre is hosted on Elsevier Connect, and Elsevier grants permission to make all its COVID-19-related research freely available in PubMed Central and other public repositories. A study reports an unusual cluster of eight children with hyperinflammatory shock during the 2020 pandemic, resembling atypical Kawasaki disease or toxic shock syndrome. These children, previously healthy, showed symptoms like high fever, rash, and gastrointestinal issues. Despite testing negative for SARS-CoV-2, they developed severe shock requiring intensive care. Some had cardiac complications, including coronary aneurysms. All received intravenous immunoglobulin and antibiotics, with most recovering. Two later tested positive for SARS-CoV-2. The study suggests a new syndrome in previously asymptomatic children, similar to Kawasaki disease shock syndrome. Elsevier also highlights a study on PCR screening of asymptomatic healthcare workers at a London hospital. The UK's COVID-19 outbreak was controlled by social distancing and lockdown. Asymptomatic infection testing is crucial for understanding disease spread and immunity. A study at Barts Health NHS Trust collected data from asymptomatic healthcare workers over 16 weeks, including nasal swabs and blood samples. The study aimed to identify factors influencing asymptomatic infection and immunity. The case-doubling time in London was around 3-4 days in March 2020. The study underscores the importance of understanding asymptomatic cases for public health strategies.
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[slides and audio] Hyperinflammatory shock in children during COVID-19 pandemic