The study investigates the relationship between hyperinsulinemia and ischemic heart disease (IHD) in a cohort of 2103 men from Quebec City, Canada. The researchers collected blood samples from these men in 1985 and followed them for five years to identify cases of IHD. After excluding diabetic participants, they compared fasting plasma insulin and lipoprotein concentrations between 91 case patients and 105 controls. The results showed that case patients had 18% higher fasting insulin levels than controls (P<0.001). Logistic regression analysis revealed that higher insulin concentrations were independently associated with an increased risk of IHD, with an odds ratio of 1.7 (95% CI, 1.3 to 2.4) for each standard deviation increase in insulin levels, after adjusting for systolic blood pressure, medication use, and family history of IHD. Further adjustments for triglycerides, apolipoprotein B, LDL cholesterol, and HDL cholesterol did not significantly alter this association. The findings suggest that high fasting insulin concentrations are an independent predictor of IHD in men, independent of other risk factors such as lipid profiles.The study investigates the relationship between hyperinsulinemia and ischemic heart disease (IHD) in a cohort of 2103 men from Quebec City, Canada. The researchers collected blood samples from these men in 1985 and followed them for five years to identify cases of IHD. After excluding diabetic participants, they compared fasting plasma insulin and lipoprotein concentrations between 91 case patients and 105 controls. The results showed that case patients had 18% higher fasting insulin levels than controls (P<0.001). Logistic regression analysis revealed that higher insulin concentrations were independently associated with an increased risk of IHD, with an odds ratio of 1.7 (95% CI, 1.3 to 2.4) for each standard deviation increase in insulin levels, after adjusting for systolic blood pressure, medication use, and family history of IHD. Further adjustments for triglycerides, apolipoprotein B, LDL cholesterol, and HDL cholesterol did not significantly alter this association. The findings suggest that high fasting insulin concentrations are an independent predictor of IHD in men, independent of other risk factors such as lipid profiles.