Hyperuricemia (HUA) is a metabolic disorder caused by purine metabolism disorders, leading to elevated serum uric acid (SUA) levels. It is closely associated with gout, hypertension, diabetes, and chronic kidney disease. Traditional Chinese Medicine (TCM) shows promising results in treating HUA due to its multi-target and multi-metabolite properties. This review summarizes the progress in HUA model construction and TCM interventions. It discusses the advantages and limitations of various HUA models for efficacy evaluation and the application of TCM in HUA treatment. The paper highlights recent research on HUA model construction and systematic TCM interventions, providing a scientific reference for establishing HUA models and suggesting future TCM-related HUA studies. HUA is primarily treated through lifestyle changes or pharmacotherapy to reduce SUA levels. Lifestyle modifications include low-purine diets, quitting smoking and alcohol, exercise, and weight control. Pharmacotherapy includes drugs that inhibit UA production, promote UA excretion, and promote UA decomposition. However, these drugs have side effects and clinical limitations. TCM offers a safer and more effective alternative for HUA treatment. The pathogenesis of HUA involves an imbalance in SUA metabolism, leading to excessive UA production or impaired renal excretion. UA is synthesized in the liver and excreted through the kidneys and intestines. The excretion process involves UA transporters, such as SLC and ABC transporters, which maintain UA homeostasis. Abnormal expression of these transporters leads to UA accumulation and HUA. In TCM, HUA is associated with kidney qi deficiency, zang-fu disorders, and phlegm-blood stasis. The spleen plays a key role in transporting and transforming nutrients, and its dysfunction can lead to excessive UA production. The liver controls the conveyance and dispersion of body fluids, and its dysfunction can lead to reduced UA excretion. TCM aims to tonify the spleen and kidney, eliminate dampness and turbidity, and promote blood circulation to treat HUA. Various HUA models, including cell models and animal models, are used to evaluate the efficacy of TCM interventions. Cell models include kidney, liver, and intestinal cell lines, while animal models include rodents, primates, and zebrafish. These models help in screening UA-lowering drugs and understanding the mechanisms of TCM interventions. TCM treatments for HUA include single-botanical drugs, damp-clearing drugs, antipyretic drugs, and deficiency-tonifying drugs. These drugs reduce UA production, promote UA excretion, inhibit urate oxidase activity, and regulate inflammatory factors. TCM offers a promising alternative to conventional pharmacotherapy for HUA treatment.Hyperuricemia (HUA) is a metabolic disorder caused by purine metabolism disorders, leading to elevated serum uric acid (SUA) levels. It is closely associated with gout, hypertension, diabetes, and chronic kidney disease. Traditional Chinese Medicine (TCM) shows promising results in treating HUA due to its multi-target and multi-metabolite properties. This review summarizes the progress in HUA model construction and TCM interventions. It discusses the advantages and limitations of various HUA models for efficacy evaluation and the application of TCM in HUA treatment. The paper highlights recent research on HUA model construction and systematic TCM interventions, providing a scientific reference for establishing HUA models and suggesting future TCM-related HUA studies. HUA is primarily treated through lifestyle changes or pharmacotherapy to reduce SUA levels. Lifestyle modifications include low-purine diets, quitting smoking and alcohol, exercise, and weight control. Pharmacotherapy includes drugs that inhibit UA production, promote UA excretion, and promote UA decomposition. However, these drugs have side effects and clinical limitations. TCM offers a safer and more effective alternative for HUA treatment. The pathogenesis of HUA involves an imbalance in SUA metabolism, leading to excessive UA production or impaired renal excretion. UA is synthesized in the liver and excreted through the kidneys and intestines. The excretion process involves UA transporters, such as SLC and ABC transporters, which maintain UA homeostasis. Abnormal expression of these transporters leads to UA accumulation and HUA. In TCM, HUA is associated with kidney qi deficiency, zang-fu disorders, and phlegm-blood stasis. The spleen plays a key role in transporting and transforming nutrients, and its dysfunction can lead to excessive UA production. The liver controls the conveyance and dispersion of body fluids, and its dysfunction can lead to reduced UA excretion. TCM aims to tonify the spleen and kidney, eliminate dampness and turbidity, and promote blood circulation to treat HUA. Various HUA models, including cell models and animal models, are used to evaluate the efficacy of TCM interventions. Cell models include kidney, liver, and intestinal cell lines, while animal models include rodents, primates, and zebrafish. These models help in screening UA-lowering drugs and understanding the mechanisms of TCM interventions. TCM treatments for HUA include single-botanical drugs, damp-clearing drugs, antipyretic drugs, and deficiency-tonifying drugs. These drugs reduce UA production, promote UA excretion, inhibit urate oxidase activity, and regulate inflammatory factors. TCM offers a promising alternative to conventional pharmacotherapy for HUA treatment.