This article reviews the progress in model construction and traditional Chinese medicine (TCM) interventions for hyperuricemia (HUA), a metabolic disease characterized by elevated serum uric acid (SUA) levels. HUA is associated with various health issues, including gout, hypertension, diabetes, and chronic kidney diseases. TCM, with its multi-metabolite and multi-target advantages, has shown promising results in treating HUA. The article discusses the use of TCM components for uric acid (UA)-lowering activity, highlighting their efficacy and low side effects based on established HUA models. It also summarizes the advantages and limitations of various HUA disease models for efficacy evaluation and provides detailed discussions on TCM applications in HUA treatment. The review covers cell models, animal models, and genetic engineering methods for HUA modeling, as well as the therapeutic effects of single-botanical drugs and other TCM interventions. The paper aims to provide a scientific reference for establishing HUA models and suggest future TCM-related HUA studies.This article reviews the progress in model construction and traditional Chinese medicine (TCM) interventions for hyperuricemia (HUA), a metabolic disease characterized by elevated serum uric acid (SUA) levels. HUA is associated with various health issues, including gout, hypertension, diabetes, and chronic kidney diseases. TCM, with its multi-metabolite and multi-target advantages, has shown promising results in treating HUA. The article discusses the use of TCM components for uric acid (UA)-lowering activity, highlighting their efficacy and low side effects based on established HUA models. It also summarizes the advantages and limitations of various HUA disease models for efficacy evaluation and provides detailed discussions on TCM applications in HUA treatment. The review covers cell models, animal models, and genetic engineering methods for HUA modeling, as well as the therapeutic effects of single-botanical drugs and other TCM interventions. The paper aims to provide a scientific reference for establishing HUA models and suggest future TCM-related HUA studies.