This review article explores the role of hypoxia and oxidative stress in tendon degeneration, focusing on their molecular mechanisms and potential therapeutic strategies. Tendinopathy, a debilitating condition characterized by degenerative changes in tendons, is influenced by both intrinsic and extrinsic factors. The study highlights the significance of physiological factors such as hypoxia and oxidative stress, which have been less explored compared to intrinsic and extrinsic factors. Hypoxia, a common feature of tendon injuries, triggers the overexpression of hypoxia-inducible factor (HIF-1), which regulates various cellular processes including angiogenesis, inflammation, and apoptosis. Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) and antioxidants, is another physiological condition implicated in tendon disorders. The review discusses the impact of HIF-1 and oxidative stress on tendon health, emphasizing the potential of targeting these factors to enhance tendon repair. In vitro and in vivo studies demonstrate that regulating HIF-1 and oxidative stress can promote tendon healing, suggesting that these pathways may serve as novel therapeutic targets for tendinopathy.This review article explores the role of hypoxia and oxidative stress in tendon degeneration, focusing on their molecular mechanisms and potential therapeutic strategies. Tendinopathy, a debilitating condition characterized by degenerative changes in tendons, is influenced by both intrinsic and extrinsic factors. The study highlights the significance of physiological factors such as hypoxia and oxidative stress, which have been less explored compared to intrinsic and extrinsic factors. Hypoxia, a common feature of tendon injuries, triggers the overexpression of hypoxia-inducible factor (HIF-1), which regulates various cellular processes including angiogenesis, inflammation, and apoptosis. Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) and antioxidants, is another physiological condition implicated in tendon disorders. The review discusses the impact of HIF-1 and oxidative stress on tendon health, emphasizing the potential of targeting these factors to enhance tendon repair. In vitro and in vivo studies demonstrate that regulating HIF-1 and oxidative stress can promote tendon healing, suggesting that these pathways may serve as novel therapeutic targets for tendinopathy.