Cervical cancer (CC) is a significant gynecological malignancy, and lipid metabolism plays a crucial role in tumor proliferation and metastasis. This study investigates the molecular mechanism linking CC and lipid metabolism, focusing on the role of IGF2BP3. The expression of IGF2BP3 was found to be significantly higher in CC tissues compared to adjacent normal tissues, and it positively correlated with tumor stage. RNA-seq analysis revealed that IGF2BP3 upregulates the expression of SCD, a key enzyme in lipid metabolism. Further experiments showed that IGF2BP3 enhances lipid metabolism in CC cells by regulating SCD mRNA m6A modifications through the IGF2BP3-METTL14 complex. Knockdown of IGF2BP3 restrained CC growth and lipid metabolism, while SCD overexpression partially rescued these effects in vitro and in vivo using a nude mouse model. These findings highlight the importance of IGF2BP3 in CC progression and suggest a potential therapeutic strategy targeting IGF2BP3 and SCD to treat CC.Cervical cancer (CC) is a significant gynecological malignancy, and lipid metabolism plays a crucial role in tumor proliferation and metastasis. This study investigates the molecular mechanism linking CC and lipid metabolism, focusing on the role of IGF2BP3. The expression of IGF2BP3 was found to be significantly higher in CC tissues compared to adjacent normal tissues, and it positively correlated with tumor stage. RNA-seq analysis revealed that IGF2BP3 upregulates the expression of SCD, a key enzyme in lipid metabolism. Further experiments showed that IGF2BP3 enhances lipid metabolism in CC cells by regulating SCD mRNA m6A modifications through the IGF2BP3-METTL14 complex. Knockdown of IGF2BP3 restrained CC growth and lipid metabolism, while SCD overexpression partially rescued these effects in vitro and in vivo using a nude mouse model. These findings highlight the importance of IGF2BP3 in CC progression and suggest a potential therapeutic strategy targeting IGF2BP3 and SCD to treat CC.