15 March 2024 | D. A. Thompson · M. Bach · J. J. McAnany · M. Šuštar Habjan · S. Viswanathan · A. G. Robson
The ISCEV Standard for Clinical Pattern Electroretinography (PERG) 2024 update provides updated guidelines for PERG testing, replacing the 2013 version. The standard specifies minimum protocols for stimuli, recording methods, and reporting to ensure consistency in diagnosis and monitoring. Key changes include expanded guidance on large stimulus fields, simultaneous PERG and PVEP recording, baseline drift correction, and consistent ambient lighting. The standard also defines a stimulus check width that divides evenly into the stimulus field and specifies a reversal rate of 4.0 rps ± 1.0 rps. The PERG is a localized retinal response to a contrast-reversing pattern, primarily reflecting retinal ganglion cell (RGC) and macular cone function. The waveform includes P50 and N95 components, with N95 amplitude being a sensitive indicator of RGC function. The standard emphasizes the importance of accurate stimulus parameters, such as contrast, luminance, and field size, to ensure reliable results. It also outlines electrode placement, recording equipment, and data analysis procedures. The standard includes optional methods for large field PERGs and simultaneous PERG and PVEP recordings. The PERG is influenced by optical factors and can be used to differentiate between macular cone dysfunction and RGC or optic nerve pathway dysfunction. The standard also addresses non-standard methods, such as steady-state PERG and large check widths, and provides guidance on calibration, artifact rejection, and data reporting. The standard aims to facilitate high-quality recordings and inter-laboratory comparisons by ensuring consistent protocols and reference ranges.The ISCEV Standard for Clinical Pattern Electroretinography (PERG) 2024 update provides updated guidelines for PERG testing, replacing the 2013 version. The standard specifies minimum protocols for stimuli, recording methods, and reporting to ensure consistency in diagnosis and monitoring. Key changes include expanded guidance on large stimulus fields, simultaneous PERG and PVEP recording, baseline drift correction, and consistent ambient lighting. The standard also defines a stimulus check width that divides evenly into the stimulus field and specifies a reversal rate of 4.0 rps ± 1.0 rps. The PERG is a localized retinal response to a contrast-reversing pattern, primarily reflecting retinal ganglion cell (RGC) and macular cone function. The waveform includes P50 and N95 components, with N95 amplitude being a sensitive indicator of RGC function. The standard emphasizes the importance of accurate stimulus parameters, such as contrast, luminance, and field size, to ensure reliable results. It also outlines electrode placement, recording equipment, and data analysis procedures. The standard includes optional methods for large field PERGs and simultaneous PERG and PVEP recordings. The PERG is influenced by optical factors and can be used to differentiate between macular cone dysfunction and RGC or optic nerve pathway dysfunction. The standard also addresses non-standard methods, such as steady-state PERG and large check widths, and provides guidance on calibration, artifact rejection, and data reporting. The standard aims to facilitate high-quality recordings and inter-laboratory comparisons by ensuring consistent protocols and reference ranges.