ITRUSST Consensus on Standardised Reporting for Transcranial Ultrasound Stimulation

ITRUSST Consensus on Standardised Reporting for Transcranial Ultrasound Stimulation

Feb 2024 | Eleanor Martin, Jean-François Aubry, Mark Schafer, Lennart Verhagen, Bradley Treeby, Kim Butts Pauly
The ITRUSST Consensus on Standardised Reporting for Transcranial Ultrasound Stimulation outlines a framework for consistent reporting of transcranial ultrasound stimulation (TUS) studies. As TUS becomes a more widely used non-invasive neuromodulation technique, standardized reporting is essential for ensuring reproducibility and comparability across studies. This guide provides a checklist for reporting key parameters in TUS experiments, including the transducer and drive system, free field acoustic parameters, pulse timing parameters, and in situ estimates of exposure parameters. The guide focuses on ultrasound aspects of TUS and does not address other elements such as EEG, fMRI, or behavioral readouts. It also does not establish safety values or thresholds, which are addressed in a separate ITRUSST consensus on TUS safety. The guide aligns with existing international standards for diagnostic ultrasound imaging and focused ultrasound transducers, while making the assumption that the ultrasound fields are linear. The guide includes detailed explanations of each parameter, along with discussions on assumptions, measurements, and calculations. It also provides recommendations for reporting average or ranges of parameters. The guide is structured into sections covering system and free field acoustic pressure parameters, pulse timing parameters, derived parameters, and neuromodulation dose parameters. The guide aims to ensure that TUS studies are reported consistently, enabling better understanding and reproducibility of results.The ITRUSST Consensus on Standardised Reporting for Transcranial Ultrasound Stimulation outlines a framework for consistent reporting of transcranial ultrasound stimulation (TUS) studies. As TUS becomes a more widely used non-invasive neuromodulation technique, standardized reporting is essential for ensuring reproducibility and comparability across studies. This guide provides a checklist for reporting key parameters in TUS experiments, including the transducer and drive system, free field acoustic parameters, pulse timing parameters, and in situ estimates of exposure parameters. The guide focuses on ultrasound aspects of TUS and does not address other elements such as EEG, fMRI, or behavioral readouts. It also does not establish safety values or thresholds, which are addressed in a separate ITRUSST consensus on TUS safety. The guide aligns with existing international standards for diagnostic ultrasound imaging and focused ultrasound transducers, while making the assumption that the ultrasound fields are linear. The guide includes detailed explanations of each parameter, along with discussions on assumptions, measurements, and calculations. It also provides recommendations for reporting average or ranges of parameters. The guide is structured into sections covering system and free field acoustic pressure parameters, pulse timing parameters, derived parameters, and neuromodulation dose parameters. The guide aims to ensure that TUS studies are reported consistently, enabling better understanding and reproducibility of results.
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