A genome-wide association study (GWAS) identified seven loci associated with mean leukocyte telomere length (LTL), including five novel loci. These loci include genes involved in telomere biology, such as TERC, TERT, NAF1, OBFC1, and RTEL1. Variants at these loci were associated with several diseases, including cancer and idiopathic pulmonary fibrosis. A genetic risk score combining variants from all seven loci showed an association with increased risk of coronary artery disease (CAD), with shorter LTL linked to higher CAD risk. Telomere length is critical for genomic stability and cellular function, and variations in LTL are linked to age-related diseases. The study confirmed two previously reported loci and identified five new ones, highlighting the role of telomere length in disease susceptibility. The findings suggest a causal relationship between telomere length variation and age-related diseases, emphasizing the importance of genetic factors in telomere biology. The study also explored the functional implications of the identified loci, including their potential regulatory roles and associations with telomerase activity. Overall, the research provides new insights into the genetic determinants of telomere length and its implications for health and disease.A genome-wide association study (GWAS) identified seven loci associated with mean leukocyte telomere length (LTL), including five novel loci. These loci include genes involved in telomere biology, such as TERC, TERT, NAF1, OBFC1, and RTEL1. Variants at these loci were associated with several diseases, including cancer and idiopathic pulmonary fibrosis. A genetic risk score combining variants from all seven loci showed an association with increased risk of coronary artery disease (CAD), with shorter LTL linked to higher CAD risk. Telomere length is critical for genomic stability and cellular function, and variations in LTL are linked to age-related diseases. The study confirmed two previously reported loci and identified five new ones, highlighting the role of telomere length in disease susceptibility. The findings suggest a causal relationship between telomere length variation and age-related diseases, emphasizing the importance of genetic factors in telomere biology. The study also explored the functional implications of the identified loci, including their potential regulatory roles and associations with telomerase activity. Overall, the research provides new insights into the genetic determinants of telomere length and its implications for health and disease.