Immune cell migration is essential for effective immune responses and is regulated by both cellular and environmental factors, including cell surface receptors and their ligands. This review discusses the mechanisms governing immune cell migration, focusing on myeloid and lymphoid cells, and highlights the role of chemokine signaling, adhesion molecules, and the tumor microenvironment in immune cell trafficking to cancer. Key determinants of immune cell migration include adhesion molecules such as integrins, selectins, and their ligands, which facilitate immune cell movement and interaction with tissues. Different migration patterns, such as chemotaxis, haptotaxis, and durotaxis, are influenced by environmental cues and cell state. Tumor-specific elements, including the secretome, can alter immune cell dynamics within the tumor, either promoting or suppressing tumor growth. The review also explores the role of chemokines in T cell migration to cancer, emphasizing the dual roles of chemokine receptors and their ligands in both antitumor and protumor contexts. Additionally, the importance of immune cell trafficking in cancer immunotherapy is discussed, highlighting potential therapeutic targets for controlled immune cell delivery to tumors. The review underscores the complexity of immune cell migration in cancer and the need for further research to fully understand the mechanisms involved.Immune cell migration is essential for effective immune responses and is regulated by both cellular and environmental factors, including cell surface receptors and their ligands. This review discusses the mechanisms governing immune cell migration, focusing on myeloid and lymphoid cells, and highlights the role of chemokine signaling, adhesion molecules, and the tumor microenvironment in immune cell trafficking to cancer. Key determinants of immune cell migration include adhesion molecules such as integrins, selectins, and their ligands, which facilitate immune cell movement and interaction with tissues. Different migration patterns, such as chemotaxis, haptotaxis, and durotaxis, are influenced by environmental cues and cell state. Tumor-specific elements, including the secretome, can alter immune cell dynamics within the tumor, either promoting or suppressing tumor growth. The review also explores the role of chemokines in T cell migration to cancer, emphasizing the dual roles of chemokine receptors and their ligands in both antitumor and protumor contexts. Additionally, the importance of immune cell trafficking in cancer immunotherapy is discussed, highlighting potential therapeutic targets for controlled immune cell delivery to tumors. The review underscores the complexity of immune cell migration in cancer and the need for further research to fully understand the mechanisms involved.