The article provides an overview of the current state of knowledge regarding the immune response to SARS-CoV-2, focusing on both innate and adaptive immune responses. It discusses the mechanisms by which the virus evades innate immune sensing, the role of myeloid cells in driving pathogenic inflammation, and the impact of T and B cell responses on disease severity. The article highlights the importance of understanding these immune responses to develop effective treatments and vaccines for COVID-19. Key findings include the dysregulation of IFN-I response, the recruitment and activation of inflammatory monocytes, and the potential for targeted immunosuppressive treatments. The article also reviews the role of NK cells, helper ILCs, and T cells in SARS-CoV-2 infection, emphasizing the need for further research to understand their contributions to disease pathogenesis. Additionally, it discusses the development and lifespan of B cell memory responses, suggesting that robust antibody responses may offer protection against reinfection.The article provides an overview of the current state of knowledge regarding the immune response to SARS-CoV-2, focusing on both innate and adaptive immune responses. It discusses the mechanisms by which the virus evades innate immune sensing, the role of myeloid cells in driving pathogenic inflammation, and the impact of T and B cell responses on disease severity. The article highlights the importance of understanding these immune responses to develop effective treatments and vaccines for COVID-19. Key findings include the dysregulation of IFN-I response, the recruitment and activation of inflammatory monocytes, and the potential for targeted immunosuppressive treatments. The article also reviews the role of NK cells, helper ILCs, and T cells in SARS-CoV-2 infection, emphasizing the need for further research to understand their contributions to disease pathogenesis. Additionally, it discusses the development and lifespan of B cell memory responses, suggesting that robust antibody responses may offer protection against reinfection.