The article discusses the immunology of psoriasis, a chronic inflammatory skin disease mediated by T cells and dendritic cells. It highlights the role of cytokines such as IL-23, IL-17, and TNF in psoriasis pathogenesis, and explores the genetic basis of the disease, including key loci and single nucleotide polymorphisms. The article reviews the relationship between psoriasis and comorbidities, such as cardiovascular disease, diabetes, and cancer, and discusses the molecular mechanisms underlying psoriasis, including the role of keratinocytes, T cells, and dendritic cells. It also examines the role of myeloid dendritic cells in psoriasis, the involvement of T cells in the disease, and the contributions of natural killer cells and NKT cells. The article discusses the genetic background of psoriasis, including mutations in genes such as CARD14 and IL36RN, and their effects on the immune system. It also reviews the use of mouse models to study psoriasis and the integration of genetic and transcriptomic data to understand the disease. The article concludes with a discussion of the relationship between psoriasis and systemic inflammation, and the potential for targeted therapies based on these findings.The article discusses the immunology of psoriasis, a chronic inflammatory skin disease mediated by T cells and dendritic cells. It highlights the role of cytokines such as IL-23, IL-17, and TNF in psoriasis pathogenesis, and explores the genetic basis of the disease, including key loci and single nucleotide polymorphisms. The article reviews the relationship between psoriasis and comorbidities, such as cardiovascular disease, diabetes, and cancer, and discusses the molecular mechanisms underlying psoriasis, including the role of keratinocytes, T cells, and dendritic cells. It also examines the role of myeloid dendritic cells in psoriasis, the involvement of T cells in the disease, and the contributions of natural killer cells and NKT cells. The article discusses the genetic background of psoriasis, including mutations in genes such as CARD14 and IL36RN, and their effects on the immune system. It also reviews the use of mouse models to study psoriasis and the integration of genetic and transcriptomic data to understand the disease. The article concludes with a discussion of the relationship between psoriasis and systemic inflammation, and the potential for targeted therapies based on these findings.