The article "Impact of Aging on Cardiovascular Diseases" by Dong Zhao, Yibin Wang, Nathan D. Wong, and Jian'an Wang, published in JACC: Asia 2024, explores the growing challenges of cardiovascular disease (CVD) in an increasingly aging global population. Despite significant progress in reducing age-standardized CVD mortality, the absolute number of CVD-related deaths has increased due to demographic shifts towards older populations. The authors highlight the need to understand the biological aging process and its impact on CVD, which has been underexplored in previous reviews. The review aims to bridge the gap between chronological aging and biological aging by addressing critical questions about the relationship between biological aging and CVD. It emphasizes that while chronological age is a significant factor in CVD risk assessment, biological age, influenced by genetic and lifestyle factors, may play a more crucial role in disease progression. The authors analyze age-specific CVD mortality data from the Global Burden of Disease (GBD) database, showing an exponential increase in CVD mortality with age, particularly in older adults. The review also examines the impact of biological aging on vascular diseases across different arterial territories, using data from large-scale studies and autopsies. It discusses the potential synergistic effects of biological aging and modifiable risk factors, such as hypertension, dyslipidemia, smoking, diabetes, and obesity, on CVD risk. The authors find that the biological aging process may be modifiable through interventions targeting risk factors and socioeconomic disparities. Additionally, the article compares the patterns of age-related CVD and cancer mortality, noting distinct differences in their age-specific trends. It suggests that different organs or systems may have unique hallmarks of aging, which could explain the varying effects of biological aging on these two diseases. The authors conclude that the impact of biological aging on CVD is a synergistic effect of intrinsic biological aging, modifiable risk factors, and socioeconomic development levels. They emphasize the need for further research to translate biological aging insights into practical interventions for healthy aging and CVD prevention.The article "Impact of Aging on Cardiovascular Diseases" by Dong Zhao, Yibin Wang, Nathan D. Wong, and Jian'an Wang, published in JACC: Asia 2024, explores the growing challenges of cardiovascular disease (CVD) in an increasingly aging global population. Despite significant progress in reducing age-standardized CVD mortality, the absolute number of CVD-related deaths has increased due to demographic shifts towards older populations. The authors highlight the need to understand the biological aging process and its impact on CVD, which has been underexplored in previous reviews. The review aims to bridge the gap between chronological aging and biological aging by addressing critical questions about the relationship between biological aging and CVD. It emphasizes that while chronological age is a significant factor in CVD risk assessment, biological age, influenced by genetic and lifestyle factors, may play a more crucial role in disease progression. The authors analyze age-specific CVD mortality data from the Global Burden of Disease (GBD) database, showing an exponential increase in CVD mortality with age, particularly in older adults. The review also examines the impact of biological aging on vascular diseases across different arterial territories, using data from large-scale studies and autopsies. It discusses the potential synergistic effects of biological aging and modifiable risk factors, such as hypertension, dyslipidemia, smoking, diabetes, and obesity, on CVD risk. The authors find that the biological aging process may be modifiable through interventions targeting risk factors and socioeconomic disparities. Additionally, the article compares the patterns of age-related CVD and cancer mortality, noting distinct differences in their age-specific trends. It suggests that different organs or systems may have unique hallmarks of aging, which could explain the varying effects of biological aging on these two diseases. The authors conclude that the impact of biological aging on CVD is a synergistic effect of intrinsic biological aging, modifiable risk factors, and socioeconomic development levels. They emphasize the need for further research to translate biological aging insights into practical interventions for healthy aging and CVD prevention.