The article reviews the role of gonadotropin-inhibitory hormone (GnIH) in stress-induced male infertility. It highlights that GnIH plays a crucial role in the hypothalamic-pituitary-adrenal (HPA) axis, hypothalamic-pituitary-thyroidal (HPT) axis, and hypothalamic-pituitary-gonadal (HPG) axis. Under stressful conditions, GnIH enhances the release of corticosteroids, inhibits the conversion of thyroxine (T4) to triiodothyronine (T3), and suppresses gonadotropin-releasing hormone (GnRH), leading to reduced testosterone levels and impaired spermatogenesis. Additionally, GnIH inhibits kisspeptin release, affecting puberty onset and sperm quality. The study concludes that GnIH's multiple mechanisms contribute to stress-induced male infertility, and suppressing GnIH may be a beneficial strategy to prevent or treat this condition.The article reviews the role of gonadotropin-inhibitory hormone (GnIH) in stress-induced male infertility. It highlights that GnIH plays a crucial role in the hypothalamic-pituitary-adrenal (HPA) axis, hypothalamic-pituitary-thyroidal (HPT) axis, and hypothalamic-pituitary-gonadal (HPG) axis. Under stressful conditions, GnIH enhances the release of corticosteroids, inhibits the conversion of thyroxine (T4) to triiodothyronine (T3), and suppresses gonadotropin-releasing hormone (GnRH), leading to reduced testosterone levels and impaired spermatogenesis. Additionally, GnIH inhibits kisspeptin release, affecting puberty onset and sperm quality. The study concludes that GnIH's multiple mechanisms contribute to stress-induced male infertility, and suppressing GnIH may be a beneficial strategy to prevent or treat this condition.