This study presents a novel approach to enhance the performance of hydrogen oxidation reaction (HOR) catalysts by implanting oxophilic metal atoms into PtRu nanowires. The research demonstrates that dual doping with In and Zn atoms significantly improves the HOR activity and stability of PtRu nanowires. The optimal catalyst, i-ZnIn-PR/C, exhibits a mass activity of 10.2 A mg⁻¹ at 50 mV, surpassing commercial Pt/C and PtRu/C. The catalyst also shows high stability and resistance to CO poisoning, with a current decay of only 5.3% after 10,000 seconds. When used in an anion exchange membrane fuel cell (AEMFC), i-ZnIn-PR/C achieves a peak power density of 1.84 W cm⁻² and a specific power density of 18.4 W mg⁻¹. Advanced experimental characterizations and theoretical calculations reveal that the dual doping optimizes the binding strengths of intermediates and promotes CO oxidation, enhancing HOR performance. The study highlights the potential of oxophilic metal doping in developing efficient and stable catalysts for alkaline HOR, which could have significant implications for sustainable energy technologies.This study presents a novel approach to enhance the performance of hydrogen oxidation reaction (HOR) catalysts by implanting oxophilic metal atoms into PtRu nanowires. The research demonstrates that dual doping with In and Zn atoms significantly improves the HOR activity and stability of PtRu nanowires. The optimal catalyst, i-ZnIn-PR/C, exhibits a mass activity of 10.2 A mg⁻¹ at 50 mV, surpassing commercial Pt/C and PtRu/C. The catalyst also shows high stability and resistance to CO poisoning, with a current decay of only 5.3% after 10,000 seconds. When used in an anion exchange membrane fuel cell (AEMFC), i-ZnIn-PR/C achieves a peak power density of 1.84 W cm⁻² and a specific power density of 18.4 W mg⁻¹. Advanced experimental characterizations and theoretical calculations reveal that the dual doping optimizes the binding strengths of intermediates and promotes CO oxidation, enhancing HOR performance. The study highlights the potential of oxophilic metal doping in developing efficient and stable catalysts for alkaline HOR, which could have significant implications for sustainable energy technologies.