The article discusses the potential diagnosis of cholesterol crystal embolization in a patient who experienced skin necrosis following streptokinase treatment. The diagnosis can be confirmed through histological findings of cholesterol crystals in small and medium-sized arteries, which may require repeated biopsies. The authors also highlight the importance of combining data from clinically based datasets and cancer registries to improve the accuracy of treatment outcomes and patient care. Additionally, they address the issue of hepatitis B immunization and reactive arthritis, suggesting that sexually acquired reactive arthritis should be considered in such cases. The article further explores the concept of implicit memory during general anesthesia and the methods used to monitor its presence. Finally, the authors clarify misconceptions about the Cochrane Collaboration, emphasizing its broad scope, transparency, and commitment to continuous improvement.The article discusses the potential diagnosis of cholesterol crystal embolization in a patient who experienced skin necrosis following streptokinase treatment. The diagnosis can be confirmed through histological findings of cholesterol crystals in small and medium-sized arteries, which may require repeated biopsies. The authors also highlight the importance of combining data from clinically based datasets and cancer registries to improve the accuracy of treatment outcomes and patient care. Additionally, they address the issue of hepatitis B immunization and reactive arthritis, suggesting that sexually acquired reactive arthritis should be considered in such cases. The article further explores the concept of implicit memory during general anesthesia and the methods used to monitor its presence. Finally, the authors clarify misconceptions about the Cochrane Collaboration, emphasizing its broad scope, transparency, and commitment to continuous improvement.