In vivo human retinal imaging by Fourier domain optical coherence tomography

In vivo human retinal imaging by Fourier domain optical coherence tomography

July 2002 | Maciej Wojtkowski, Rainer Leitgeb, Andrzej Kowalczyk, Tomasz Bajraszewski, Adolf F. Fercher
This paper presents a modified version of Fourier domain optical coherence tomography (FDOCT) for in vivo retinal imaging. FDOCT, which provides high-resolution, non-contact imaging, has been increasingly used in ophthalmic diagnostics, particularly for detecting and monitoring macular diseases and early glaucoma. The authors describe the experimental setup of their FDOCT instrument, which uses a Michelson interferometer with a superluminescent diode as the light source and a cooled CCD camera for detection. They introduce a differential FDOCT technique to eliminate parasitic terms from the data, improving the quality of the images. The dynamic range of the system is estimated to be 71 dB, and the axial resolution is determined by the coherence length of the light source. The authors demonstrate the effectiveness of their technique by obtaining detailed tomograms of the human retina, including the macula and optic disk, and quantifying the thickness of different retinal layers. The results are comparable to those obtained using conventional time-domain OCT, highlighting the potential of FDOCT for clinical applications.This paper presents a modified version of Fourier domain optical coherence tomography (FDOCT) for in vivo retinal imaging. FDOCT, which provides high-resolution, non-contact imaging, has been increasingly used in ophthalmic diagnostics, particularly for detecting and monitoring macular diseases and early glaucoma. The authors describe the experimental setup of their FDOCT instrument, which uses a Michelson interferometer with a superluminescent diode as the light source and a cooled CCD camera for detection. They introduce a differential FDOCT technique to eliminate parasitic terms from the data, improving the quality of the images. The dynamic range of the system is estimated to be 71 dB, and the axial resolution is determined by the coherence length of the light source. The authors demonstrate the effectiveness of their technique by obtaining detailed tomograms of the human retina, including the macula and optic disk, and quantifying the thickness of different retinal layers. The results are comparable to those obtained using conventional time-domain OCT, highlighting the potential of FDOCT for clinical applications.
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Understanding In vivo human retinal imaging by Fourier domain optical coherence tomography.