This study predicts the burden of osteoporosis-related fractures and associated costs in the United States from 2005 to 2025, by sex, age group, race/ethnicity, and fracture type. The total number of fractures is expected to exceed 2 million in 2005, costing nearly $17 billion. Men account for 29% of fractures and 25% of costs. Nonvertebral fractures (excluding hip and vertebral) represent 73% of total fractures and 94% of total costs. By 2025, annual fractures and costs are projected to rise by almost 50%, with the most rapid growth among people aged 65-74 years and in nonwhite populations. The study emphasizes the need for targeted intervention and treatment programs to address the growing burden of osteoporosis, particularly in men and diverse racial/ethnic subgroups.This study predicts the burden of osteoporosis-related fractures and associated costs in the United States from 2005 to 2025, by sex, age group, race/ethnicity, and fracture type. The total number of fractures is expected to exceed 2 million in 2005, costing nearly $17 billion. Men account for 29% of fractures and 25% of costs. Nonvertebral fractures (excluding hip and vertebral) represent 73% of total fractures and 94% of total costs. By 2025, annual fractures and costs are projected to rise by almost 50%, with the most rapid growth among people aged 65-74 years and in nonwhite populations. The study emphasizes the need for targeted intervention and treatment programs to address the growing burden of osteoporosis, particularly in men and diverse racial/ethnic subgroups.