2020 | Saskia Middeldorp, Michiel Coppens, Thijs F. van Haaps, Merijn Foppen, Alexander P. Vlaar, Marcella C. A. Müller, Catherine C. S. Bouman, Ludo F. M. Beenen, Ruud S. Kootte, Jarom Heijmans, Loek P. Smits, Peter I. Bonta, Nick van Es
Elsevier established a free COVID-19 resource centre in January 2020, offering information in English and Mandarin. The centre is hosted on Elsevier Connect, providing access to research for PubMed Central and other repositories.
The study investigates the incidence of venous thromboembolism (VTE) in hospitalized patients with COVID-19. It is a single-center cohort study of 198 patients. Results show that 39 patients (20%) were diagnosed with VTE, of whom 25 (13%) had symptomatic VTE. The cumulative incidence of VTE was 16%, 33%, and 42% at 7, 14, and 21 days, respectively. For symptomatic VTE, these were 10%, 21%, and 25%. VTE was associated with a higher risk of death (adjusted HR, 2.4). ICU patients had a higher incidence of VTE compared to ward patients.
Risk factors for VTE included higher white blood cell count, neutrophil-to-lymphocyte ratio, and D-dimer levels. The study highlights the high risk of VTE in ICU patients and the need for high clinical suspicion and diagnostic imaging for DVT or PE. Future research should focus on optimal diagnostic and prophylactic strategies to prevent VTE and improve survival. The study also notes that thrombosis prophylaxis was effective in reducing VTE incidence, but the risk remained high even with prophylaxis. The study concludes that the risk of VTE in COVID-19 patients is high, particularly in ICU patients, and that diagnostic imaging should be used to detect VTE. The study also emphasizes the importance of early detection and treatment of VTE to prevent complications and improve outcomes.Elsevier established a free COVID-19 resource centre in January 2020, offering information in English and Mandarin. The centre is hosted on Elsevier Connect, providing access to research for PubMed Central and other repositories.
The study investigates the incidence of venous thromboembolism (VTE) in hospitalized patients with COVID-19. It is a single-center cohort study of 198 patients. Results show that 39 patients (20%) were diagnosed with VTE, of whom 25 (13%) had symptomatic VTE. The cumulative incidence of VTE was 16%, 33%, and 42% at 7, 14, and 21 days, respectively. For symptomatic VTE, these were 10%, 21%, and 25%. VTE was associated with a higher risk of death (adjusted HR, 2.4). ICU patients had a higher incidence of VTE compared to ward patients.
Risk factors for VTE included higher white blood cell count, neutrophil-to-lymphocyte ratio, and D-dimer levels. The study highlights the high risk of VTE in ICU patients and the need for high clinical suspicion and diagnostic imaging for DVT or PE. Future research should focus on optimal diagnostic and prophylactic strategies to prevent VTE and improve survival. The study also notes that thrombosis prophylaxis was effective in reducing VTE incidence, but the risk remained high even with prophylaxis. The study concludes that the risk of VTE in COVID-19 patients is high, particularly in ICU patients, and that diagnostic imaging should be used to detect VTE. The study also emphasizes the importance of early detection and treatment of VTE to prevent complications and improve outcomes.