The COVID-19 Resource Centre, established by Elsevier in January 2020, provides free information in English and Mandarin on the novel coronavirus. Elsevier grants permission to make all COVID-19-related research available in PubMed Central and other public repositories, with unrestricted reuse and analysis rights, as long as the resource centre remains active. A single-center cohort study of 198 hospitalized patients with COVID-19 was conducted to investigate the incidence of objectively confirmed venous thromboembolism (VTE). The study found that 20% of patients were diagnosed with VTE, with 13% experiencing symptomatic VTE despite routine thrombosis prophylaxis. The cumulative incidence of VTE at 7, 14, and 21 days was 16%, 33%, and 42%, respectively. ICU patients had a higher risk of VTE compared to ward patients, with a cumulative incidence of 26%, 47%, and 59% at 7, 14, and 21 days, respectively. VTE was significantly associated with mortality, with an adjusted hazard ratio of 2.4. The study highlights the high risk of VTE in COVID-19 patients, particularly in ICU patients, and emphasizes the need for high clinical suspicion and low-threshold diagnostic imaging for DVT or PE. Future research should focus on optimal diagnostic and prophylactic strategies to prevent VTE and potentially improve survival.The COVID-19 Resource Centre, established by Elsevier in January 2020, provides free information in English and Mandarin on the novel coronavirus. Elsevier grants permission to make all COVID-19-related research available in PubMed Central and other public repositories, with unrestricted reuse and analysis rights, as long as the resource centre remains active. A single-center cohort study of 198 hospitalized patients with COVID-19 was conducted to investigate the incidence of objectively confirmed venous thromboembolism (VTE). The study found that 20% of patients were diagnosed with VTE, with 13% experiencing symptomatic VTE despite routine thrombosis prophylaxis. The cumulative incidence of VTE at 7, 14, and 21 days was 16%, 33%, and 42%, respectively. ICU patients had a higher risk of VTE compared to ward patients, with a cumulative incidence of 26%, 47%, and 59% at 7, 14, and 21 days, respectively. VTE was significantly associated with mortality, with an adjusted hazard ratio of 2.4. The study highlights the high risk of VTE in COVID-19 patients, particularly in ICU patients, and emphasizes the need for high clinical suspicion and low-threshold diagnostic imaging for DVT or PE. Future research should focus on optimal diagnostic and prophylactic strategies to prevent VTE and potentially improve survival.